Effect of Clonidine as Adjuvant in Thoracic Paravertebral Block for Patients Undergoing Breast Cancer Surgery: A Prospective, Randomized, Placebo-controlled, Double-blind Study

Anesthesia, Essays and Researches
Nairita MayurSubrata Kumar Mandal

Abstract

Postoperative pain after breast cancer surgery is unavoidable. Thoracic paravertebral block (TPVB), a locoregional anesthetic technique, has been proven successful for postoperative pain management in different thoracic surgical procedures, such as thoracotomy, breast cancer surgeries. Clonidine, an adjuvant, in TPVB may enhance the quality and prolong the duration of analgesia. This prospective study was to evaluate the effectiveness of clonidine; administered with TPVB; in addition to conventional local anesthetic solution. Fifty-two patients (25-55 years) scheduled for breast cancer surgery under general anesthesia were randomly divided into Group A (n = 26) receiving preoperative TPVB at T3 with clonidine added to local anesthesia solution and Group B (n = 26) receiving identical TPVB with local anesthesia but without any adjuvant. This was followed by balanced general anesthesia. A visual analog scale was used to assess pain postoperatively up to 48 h. Meantime to administration of the first dose of rescue analgesic was noted. Total dose of fentanyl consumption, hemodynamic parameters, and side effects were all recorded for each patient. The dosage of fentanyl required in the intraoperative period was significantly lower i...Continue Reading

References

Apr 1, 1986·American Journal of Surgery·A M CohenW C Wood
Sep 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J ParkC Chu
Aug 1, 1997·Anesthesiology·J M Bernard, P Macaire
Aug 26, 2006·Anesthesia and Analgesia·Pekka M KairaluomaPertti J Pere
Sep 1, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ellen L PoleshuckRobert H Dworkin
Nov 13, 2009·Cleveland Clinic Journal of Medicine·Gerald W Smetana
Nov 12, 2009·JAMA : the Journal of the American Medical Association·Rune GärtnerHenrik Kehlet
Apr 14, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Youssef TahiriAndreas Nikolis
Feb 9, 2013·Journal of Clinical Anesthesia·Sahar Abdel-Baky Mohamed, Hala Saad Abdel-Ghaffar
Jun 24, 2014·Regional Anesthesia and Pain Medicine·Manoj Kumar KarmakarAnthony M-H Ho
Jun 28, 2016·Brazilian Journal of Anesthesiology·Raphael Faria-SilvaAntônio Enéas Rangel de Carvalho Junior
Aug 19, 2016·Anesthesia and Analgesia·Alparslan TuranDaniel I Sessler
Jan 14, 2017·JBI Database of Systematic Reviews and Implementation Reports·Emelia Anne Gessling, Meredith Miller

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Excel
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.