PMID: 44477Dec 1, 1979

Effect of Clostridium perfringens neuraminidase on viability and antigenicity of human leukemic myeloblasts

Biomedicine / [publiée Pour L'A.A.I.C.I.G.]
C OgierP Reizenstein

Abstract

The effect of increasing concentrations of Cl. Perfringens neuraminidase and of pH on the dye exclusion ability and lymphocyte stimulating capacity of leukemic myeloblasts was studied. The higher the neuraminidase concentration, or the lower the pH was, the more myeloblasts died and the less the myeloblasts stimulated lymphocytes. Myeloblasts treated at a neutral pH and at low enzyme concentrations retained, but did not increase their antigenicity.

Related Concepts

Myeloblast
Thymidine
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Lymphoid Cells
Hairy Cell Leukemia
Neuraminidase
Clostridium perfringens
Cell Survival
Acute Myeloid Leukemia, M1
Specimen Type - Lymphocytes

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