Effect of co-monomer composition on the integrity of bioactive growth hormone released from novel PEMA based polymers

Journal of Biomedical Materials Research
C J GoodwinN J Marshall

Abstract

The release of human growth hormone (hGH) from hormone loaded bone cement was previously shown to enhance osteoid formation. hGH is a complex protein and its incorporation into such cements may compromise its bioactivity. We therefore characterized the release of hGH from a series of methacrylate systems based upon poly(ethylmethacrylate) (PEMA). Different mixtures of two monomers, hydroxyethylmethacrylate (HEMA) and n-butylmethacrylate (n-BM) were used to provide polymers with graded water uptakes. Exclusive use of only one of the monomers resulted in enhanced cytotoxicity and also reduced release of the bioactive hormone. Combinations of the monomers improved the recovery of bioactivity from the polymers and reduced their cytotoxicity. hGH released from the polymer with the lowest water uptake (100% n-BM, 0% HEMA) had an exceptionally low bioactivity: immunoactivity ratio, suggesting that the bioactive site of the hormone is particularly susceptible to disruption when it is incorporated into this matrix.

References

Jul 1, 1992·Journal of Biomedical Materials Research·K IshiharaK Furuya
Aug 1, 1991·Biomaterials·K W Davy, M Braden
Aug 1, 1987·The Journal of Bone and Joint Surgery. British Volume·B WeightmanL V Carlson
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Citations

Apr 15, 2004·Dental Materials : Official Publication of the Academy of Dental Materials·Dong XieJimmy Mays
Apr 29, 1998·Journal of Biomedical Materials Research·C J GoodwinN J Marshall

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