PMID: 6790499Jul 1, 1981

Effect of CO2 set point on ventilatory response to exercise

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
A OrenB J Whipp

Abstract

The ventilatory response to exercise was determined in seven normal adults during induced chronic metabolic acidosis, chronic metabolic alkalosis, and a control state. Incremental and constant-load exercise tests were performed in each condition on a cycle ergometer. Ventilation and gas exchange variables were determined breath by breath, and CO2 partial pressure (PCO2), pH, and HCO3 were determined from arterialized venous blood (Pa-VCO2). During chronic metabolic acidosis PaVCO2 was lower than control (36.3 +/- 2.1 and 43.7 +/- 2.9 Torr, respectively) and during alkalosis it was elevated to 47.1 +/- 1.3 Torr. The new PCO2 levels caused by chronic acid-base alterations were unchanged during moderate exercise. The ventilatory response (VE) to the same metabolic rate increment was therefore larger (delta VE = 20.6 +/- 2.91/min) when PCO2 was lower than the control level (delta VE = 14.5 +/- 2.01/min. VE also increased more steeply in response to incremental exercise tests when PCO2 was reduced. Thus the hyperpnea of moderate exercise reflects the level at which arterial PCO2 is regulated at rest, as well as the metabolic load (VCO2).

Citations

Sep 1, 1993·Annals of Biomedical Engineering·F M Bennett, W E Fordyce
Mar 1, 1996·Respirology : Official Journal of the Asian Pacific Society of Respirology·A BalgosR Pascual
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan E PrestonJohn T Fisher
Feb 19, 2010·Medicine and Science in Sports and Exercise·Tony G BabbGordon S Mitchell
Jul 1, 2017·American Journal of Respiratory and Critical Care Medicine·Alcides RochaJ Alberto Neder
Sep 28, 2004·European Journal of Applied Physiology·Tadayoshi MiyamotoKenji Sunagawa
Nov 10, 2007·Journal of Applied Physiology·Helen E WoodTony G Babb
Jan 31, 2019·Frontiers in Physiology·Jesús Álvarez-HermsMartin Burtscher
Dec 2, 2020·Annals of the American Thoracic Society·J Alberto Neder

Related Concepts

Metabolic Acidosis
Alkalosis
Arteries
Blood
Carbon Dioxide
Respiration

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