PMID: 9540457Apr 16, 1998Paper

Effect of coating of aluminum carboxymethylcellulose beads on the release and bioavailability of diclofenac sodium

Pharmaceutica acta Helvetiae
E A Hosny, al-Helw A al-R

Abstract

The production of spheres loaded with diclofenac sodium by the cross linking technique was achieved. The hydrophilic polymer sodium carboxymethylcellulose (Na-CMC) which gels in the presence of a cross linking agent, aluminum chloride (AlCl3), was used as a matrix forming agent for the bead production. To obtain a regular and uniform rate of drug release, the produced beads were coated with sodium alginate to increase the pathway of the diffused medium. Two processing variables were studied, the flocculating agent concentration (20, 40 and 60% w/v) and different coating times (15, 30 and 60 min). The results show that the higher concentrations of aluminum chloride (40 and 60% w/v) produced more uniform and rounded beads than that prepared using 20% w/v salt. The particle size of the core beads decreased insignificantly (P > 0.05) as the flocculating agent concentration increased. The coating time did not affect the particle size of the coated beads within the same concentration of aluminum chloride. The dissolution studies showed that the release rate of diclofenac sodium from the core beads increased with the increase of AlCl3 concentration and that the rate of drug release was markedly reduced after the coating of the core be...Continue Reading

Citations

Jul 27, 2005·Archives of Pharmacal Research·Mi Kyong YooChong Su Cho
Nov 1, 2012·Indian Journal of Pharmaceutical Sciences·N R KotagaleM J Umekar
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ding ZhaoJie Huang
Jan 14, 2016·Pharmaceutical Development and Technology·A Michael Rajesh, Kiritkumar Mangaldas Popat
Aug 4, 2006·Drug Development and Industrial Pharmacy·O S SilvaS C S Rocha
Apr 3, 2013·Carbohydrate Polymers·Sathasivam ThenapakiamMuniyandy Saravanan
Apr 10, 2013·International Journal of Biological Macromolecules·Shiv Sankar BhattacharyaAmitava Ghosh
Mar 30, 2013·International Journal of Biological Macromolecules·Subham BanerjeePronobesh Chattopadhyay
Sep 18, 2012·International Journal of Biological Macromolecules·Shiv Sankar BhattacharyaAmitava Ghosh
Aug 30, 2019·Current Pharmaceutical Design·Patricia SeverinoEliana B Souto

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