Effect of cocaine use on methadone pharmacokinetics in humans.

The American Journal on Addictions
Elinore F McCance-KatzPetrie M Rainey

Abstract

Chronic cocaine use has been shown to significantly decrease buprenorphine concentrations in the blood with potential for adverse events and poor treatment response. In this study, we investigated whether a similar drug interaction occurred between cocaine and methadone. In a retrospective analysis, methadone pharmacokinetics were compared for those who were either regular cocaine users (N = 16) or with intermittent or no cocaine use (N = 23). Participants who used cocaine regularly showed a significant decrease in C(min) (p = .04) and a trend for decreased AUC (p = .09) and more rapid methadone clearance (p = .08). Regular cocaine use may adversely impact treatment outcomes for opioid dependence in those receiving methadone maintenance by decreasing methadone exposure.

References

Sep 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R A DeanW F Bosron
Jan 1, 1972·Clinical Pharmacology and Therapeutics·R C Baselt, L J Casarett
Feb 1, 1997·The American Journal of Drug and Alcohol Abuse·C E GrellaS E Wugalter
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·S Casey LaizureRobert B Parker
Dec 21, 2002·Addiction·Francesco LeriJane Stewart
May 21, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wenjiang ZhangEdward M Sellers
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elinore F McCance-KatzPeter Jatlow
Jun 19, 2004·The American Journal on Addictions·Elinore F McCance-KatzPeter Jatlow
Oct 27, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna FerrariEmilio Sternieri
Mar 4, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nicolas PicardPierre Marquet
Dec 31, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Yan ChangElinore F McCance-Katz
Apr 19, 2007·Journal of Addictive Diseases·Icro MaremmaniMarc Shinderman
Feb 23, 2008·Anesthesiology·Rheem A TotahEvan D Kharasch
Jan 21, 2009·Annals of Internal Medicine·Mori J KrantzMark C P Haigney
Feb 3, 2009·Biochemical Pharmacology·Hao-Jie ZhuJohn S Markowitz

❮ Previous
Next ❯

Citations

Apr 30, 2013·European Journal of Pharmacology·Emilie BelkaïCynthia Marie-Claire
Aug 6, 1998·Journal of Psychoactive Drugs·J A HollandW N Elwood
Mar 1, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Lynn E SullivanUNKNOWN BHIVES Collaborative
Jan 10, 2012·The American Journal of Drug and Alcohol Abuse·Wesley T LindseyDarrell Childress
Dec 7, 2014·Journal of Substance Abuse Treatment·Jeanette M TetraultLynn E Fiellin
Dec 1, 2017·Expert Opinion on Pharmacotherapy·Maurice DematteisMichael Soyka
Nov 1, 2011·Critical Reviews in Clinical Laboratory Sciences·Bhushan M KapurPeter Selby
Jan 9, 2014·Pharmacological Reports : PR·Małgorzata HołujPiotr Popik
Oct 24, 2017·The Psychological Record·August F HoltynKenneth Silverman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal on Addictions
Elinore F McCance-KatzDavid E Moody
The American Journal on Addictions
Elinore F McCance-KatzPetrie M Rainey
Basic & Clinical Pharmacology & Toxicology
Kuntheavy Ing LorenziniJules Desmeules
Journal of Pain and Symptom Management
Ricardo A Cruciani
© 2021 Meta ULC. All rights reserved