Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease

The Journal of Allergy and Clinical Immunology
Jaclyn SmithAshley Woodcock

Abstract

Codeine is the standard antitussive treatment to which novel agents are compared. Little is known about the objective effect of any treatments on cough in chronic obstructive pulmonary disease (COPD). To quantify the effect of codeine on objective cough frequency (quantified as time spent coughing: cough seconds, cs/h), citric acid cough threshold, and subjective measures in a double-blind, placebo-controlled crossover study in COPD. We studied 21 patients with physician-diagnosed, stable disease who complained of cough (76.9% male; mean age, 67.7 years; mean predicted FEV(1), 53.4%; median smoking history, 43.5 pack-years). Each subject performed a cough challenge (single breath, citric acid), 10-hour daytime ambulatory and overnight cough recordings, subjective cough scores, and visual analog scales at baseline and on 2 study days, 1 week apart. Codeine phosphate 60 mg or matched placebo were given, in random order, at the start of each cough recording (0 and 12 hours). Median time spent coughing at baseline was 8.27 cs/h (interquartile range [IQR], 5.94-11.67); after placebo treatment, 7.22 cs/h (IQR 4.42-10.40); and after codeine treatment, 6.41 cs/h (IQR 3.86-9.10). Codeine treatment had a significant effect on time spent ...Continue Reading

Citations

Oct 3, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yu-long LuoWei-wei Su
Dec 11, 2007·Lung·Jaclyn Smith, Ashley Woodcock
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Donald C Bolser, Paul W Davenport
Nov 17, 2010·Respiration; International Review of Thoracic Diseases·Sophie LeconteJan Degryse
Sep 17, 2011·Respiration; International Review of Thoracic Diseases·Michael Kreuter, Felix J F Herth
Nov 24, 2006·American Journal of Respiratory and Critical Care Medicine·Alyn H MoriceRachel Thompson
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Helen SumnerJaclyn A Smith
Sep 29, 2006·Cough·Ian M PaulVasundara V Varadan
Feb 23, 2007·Cough·Arnold N HuismanJan Willem K van den Berg
Jun 23, 2010·Cough·Angela L KeyJohn E Earis
Dec 3, 2011·Cough·Sophie LeconteJean-Marie Degryse
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Jaclyn Smith, Ashley Woodcock
Oct 31, 2009·Annals of Biomedical Engineering·W T GoldsmithD G Frazer
Jan 29, 2013·Annals of Biomedical Engineering·Vinayak SwarnkarRina Triasih
Aug 10, 2013·Chest·Kristine M SchmitGillian D Sanders
Dec 19, 2014·Chest·Louis-Philippe BouletUNKNOWN CHEST Expert Cough Panel
Jun 5, 2012·Chest·Jennifer LeechMichael J Farrell
Jul 13, 2007·Chest·Samantha DecalmerJaclyn A Smith
Jul 6, 2011·Current Opinion in Pharmacology·Sarah A MaherMaria G Belvisi
Jul 5, 2011·Current Opinion in Pharmacology·Emma C Young, Jaclyn A Smith
Jan 25, 2011·Pulmonary Pharmacology & Therapeutics·Surinder S Birring
Dec 24, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kenichi MukaidaNobuoki Kohno
Feb 23, 2010·Otolaryngologic Clinics of North America·Donald C Bolser
Feb 23, 2010·Otolaryngologic Clinics of North America·Jaclyn A Smith
Oct 13, 2009·Pharmacology & Therapeutics·Julie Nasra, Maria G Belvisi
Jan 13, 2009·Pulmonary Pharmacology & Therapeutics·Kian Fan ChungJohn Widdicombe
Dec 31, 2008·Pulmonary Pharmacology & Therapeutics·Michael J Carr
Oct 10, 2008·The Journal of Allergy and Clinical Immunology·Paul A MarsdenAshley A Woodcock
Sep 6, 2008·Pulmonary Pharmacology & Therapeutics·Peter V Dicpinigaitis
Aug 19, 2008·European Journal of Pharmacology·Hiroshi TsuchidaKiyoshi Morimoto
Dec 7, 2007·Anesthesiology Clinics·Gary McCleane, Howard S Smith
Oct 24, 2007·Peptides·Richard J Bodnar
May 3, 2007·The Journal of Allergy and Clinical Immunology·David B Peden, Robert K Bush
Feb 27, 2007·The Medical Clinics of North America·Gary McCleane, Howard S Smith
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·Jaclyn Smith
Dec 13, 2006·Pulmonary Pharmacology & Therapeutics·K F Chung
Feb 19, 2008·British Journal of Clinical Pharmacology·James RamsayAlyn H Morice
Nov 28, 2006·Pulmonary Pharmacology & Therapeutics·Jack A Kastelik, Michael J Carr
Jul 15, 2015·Drug and Therapeutics Bulletin
Mar 31, 2015·Current Opinion in Pharmacology·Surinder S Birring, Arietta Spinou
Nov 20, 2012·Drug Discovery Today·Jaymin B MorjariaAlyn H Morice

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