Effect of Coenzyme Q10 on Insulin Resistance in Korean Patients with Prediabetes: A Pilot Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

BioMed Research International
Ja-Young Yoo, Keun-Sang Yum

Abstract

This study aimed to examine whether administration of coenzyme Q10, an antioxidant, improves insulin resistance in patients with prediabetes. The study design was a pilot single-center, randomized, double-blind, placebo-controlled trial. This pilot single-center, randomized, double-blind, placebo-controlled trial included a total of 80 adults (aged ≥20 years) with impaired glucose tolerance. After the initial screening visit, subjects were assigned to either the experimental (n = 40) or placebo (n = 40) group via simple randomization. Insulin resistance was represented as the insulin resistance index estimated by homeostasis model assessment (HOMA-IR). After the 8-week treatment period, the coenzyme group exhibited a significant decrease in the HOMA-IR (P < .001). The free oxygen radical and coenzyme Q10 concentrations were found to correlate significantly (P < .001). However, no significant changes in fasting blood glucose, insulin, and glycated hemoglobin levels were observed in either group. Additionally, no adverse events occurred in either group. Patients with prediabetes who were administered coenzyme Q10 showed a significant reduction in HOMA-IR values. Therefore, administration of coenzyme Q10 in patients with impaired ...Continue Reading

References

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Citations

Sep 22, 2019·Nutrients·M Elena Díaz-CasadoAlfonso Varela-López
Jul 29, 2020·Archives of Physiology and Biochemistry·Ghada E ElgarawanySuzan M Hazzaa
Feb 20, 2019·Antioxidants·David Mantle, Iain Hargreaves
Jan 15, 2021·COPD·V I ZozinaA Corlateanu
Sep 24, 2019·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisMichael Berk

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