Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers: A Randomized Clinical Trial

JAMA Network Open
Bernd StratmannDiethelm Tschoepe

Abstract

Diabetic foot ulcers are a common complication of diabetes and require specialized treatment. Cold atmospheric plasma (CAP) has been associated with benefits in wound infection and healing in previous smaller series of case reports. Yet the effect of CAP compared with standard care therapy in wound healing in diabetic foot ulcers remains to be studied. To determine whether the application of CAP accelerates wound healing in diabetic foot ulcers compared with standard care therapy. A prospective, randomized, placebo-controlled, patient-blinded clinical trial was conducted at 2 clinics with recruitment from August 17, 2016, to April 20, 2019. Patients were scheduled to remain in follow-up until April 30, 2024. Patients with diabetes and diabetic foot ulcers described using the combined Wagner-Armstrong classification of 1B or 2B (superficial or infected diabetic foot ulcers extending to tendon) were eligible. A patient could participate with 1 or more wounds in both groups in both intervention and control groups. Wounds were randomized separately, allowing a participant to be treated several times within the study following a 2 × 2 × 2 randomization strata considering sex, smoking status, and age (≤68 years and >68 years). Standa...Continue Reading

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References

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Citations

Oct 3, 2020·JAMA Network Open
Dec 18, 2020·The International Journal of Lower Extremity Wounds·Jun ZhaoHong-Lin Chen Md
Nov 25, 2020·Journal of Biophotonics·Lu GanHong Xiang Chen
Jan 7, 2021·Dermatologic Therapy·Chenchen ZhangChunjun Yang
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
Mar 16, 2021·International Journal of Antimicrobial Agents·Isabell PlattfautChristian Opländer
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco L Tabares, Ita Junkar
Oct 5, 2020·Free Radical Biology & Medicine·Anke SchmidtSander Bekeschus
May 1, 2021·Cancers·Hiromasa TanakaMounir Laroussi
May 1, 2021·International Journal of Molecular Sciences·Sander BekeschusRamona Clemen
Sep 3, 2021·Redox Biology·Sander BekeschusAnke Schmidt
Sep 15, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Alexander ThiemSteffen Emmert

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