Effect of combined dyslipidemia and hyperglycemia on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats

Journal of Toxicologic Pathology
Kiyokazu OzakiI Narama

Abstract

Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Male rats were divided into four groups: nondiabetic rats (N), alloxan-induced diabetic rats (AL), diabetic rats treated with an HFD (AH), and nondiabetic rats treated with an HFD (HF). Combined hyperglycemia and dyslipidemia (AH group) induced a significant increase in plasma triglyceride and cholesterol levels. In addition, the combined effects contributed to a reduction in myelin size and a reduction in myelin thickness as indicated on sensory sural nerve histograms. There was also a reduction in the size of motor nerve axons when compared with the effects of hyperglycemia or dyslipidemia alone. However, the sensory nerve conduction velocity in the AH group was slightly but not significantly lower than those in the HF and AL groups. These results suggest that combined hyperglycemia and dyslipidemia induced mild peripheral motor and sensory nerve lesions, without significantly affec...Continue Reading

References

Jan 1, 1977·Neurology·H PowellP Lampert
Jan 1, 1979·The Tohoku Journal of Experimental Medicine·S YagihashiM Nishihira
Dec 1, 1996·Acta Neuropathologica·K OzakiI Narama
Jan 28, 2005·The New England Journal of Medicine·Solomon TesfayeUNKNOWN EURODIAB Prospective Complications Study Group
Feb 25, 2005·American Journal of Physiology. Endocrinology and Metabolism·Christine L OltmanMark A Yorek
Sep 30, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G LauriaUNKNOWN European Federation of Neurological Societies
Feb 2, 2006·Journal of the Neurological Sciences·A Gordon Smith, J Robinson Singleton
Feb 15, 2008·Diabetes/metabolism Research and Reviews·Armin Steinmetz
May 5, 2009·Diabetes·Timothy D WigginEva L Feldman
Jul 14, 2009·Diabetes·Andrea M VincentEva L Feldman
Dec 22, 2009·Journal of the Peripheral Nervous System : JPNS·Andrea M VincentEva L Feldman
Dec 7, 2011·Experimental Diabetes Research·B L GuilfordD E Wright
Oct 13, 2012·Experimental Neurology·Lucy M HinderEva L Feldman
Jun 5, 2013·Journal of Diabetes and Its Complications·A Gordon Smith, J Robinson Singleton
Jun 12, 2013·The Journal of Veterinary Medical Science·Kiyokazu OzakiIsao Narama

❮ Previous
Next ❯

Citations

Oct 11, 2019·Investigative Ophthalmology & Visual Science·Kiyokazu OzakiTetsuro Matsuura
Jul 31, 2019·Dose-response : a Publication of International Hormesis Society·Guangju ZhouNanwei Tong
Nov 19, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Bonisiwe MbathaPhikelelani Ngubane
Feb 1, 2021·Complementary Therapies in Clinical Practice·Ahmed Essmat, Mohammed Salah Hussein

❮ Previous
Next ❯

Software Mentioned

IP Lab
JMP Pro11

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.