PMID: 2107774Apr 1, 1990Paper

Effect of combined infusion of nitroglycerin and nicardipine on femoral-to-radial arterial pressure gradient after cardiopulmonary bypass

Anesthesia and Analgesia
K MaruyamaM Kusagawa

Abstract

Nitrates and calcium channel blockers are frequently administered during cardiac surgery. We simultaneously measured femoral arterial pressure and radial arterial pressure to investigate whether nitrates, in conjunction with calcium channel blockers, would influence the central-to-peripheral arterial pressure gradient. Combined nitroglycerin and nicardipine infusion during cardiac surgery involving coronary artery bypass grafting or valve replacement resulted in a significant increase above baseline levels in the femoral-to-radial arterial pressure gradient at 60 min after cardiopulmonary bypass. In control patients there was no significant increase in the femoral-to-radial arterial pressure gradient at 60 min after completion of cardiopulmonary bypass. A subsequent study in patients given nitroglycerin and nicardipine identified that the difference in the systolic arterial pressure between femoral and radial arteries was observed 15, 60, and 120 min after completion of cardiopulmonary bypass. However, there was no difference in the mean arterial pressure between femoral and radial arteries throughout the same period. We conclude that combined infusion of nitroglycerin and nicardipine, a new calcium channel blocker, intensifies...Continue Reading

Citations

Jan 1, 1993·Journal of Anesthesia·K MaruyamaM Muneyuki
Aug 21, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·S RuizJ-M Conil
May 28, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Fadia HaddadPatricia Yazbeck
Jul 13, 2018·The International Journal of Artificial Organs·Yoshitsugu NakamuraMiho Kuroda
Apr 11, 2002·Acta Anaesthesiologica Scandinavica·A YazigiD Jawish
Nov 26, 2015·Anesthesia and Analgesia·Giuseppe FudaPierre Couture

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