Abstract
Otitis media with effusion (OME) is very common during childhood. Because Streptococcus pneumoniae is one of the most common bacterial pathogens involved in OME, pneumococcal vaccines may have a role in the prevention of recurrent OME. We sought to assess the effect of combined pneumococcal conjugate and polysaccharide vaccinations on the recurrence of OME. A randomized, controlled trial was performed with 161 children, 2 to 8 years of age, with documented persistent bilateral OME. All subjects were treated with tympanostomy tubes (TTs). One half of the subjects were assigned randomly to additional vaccination with a 7-valent pneumococcal conjugate vaccine 3 to 4 weeks before and a 23-valent pneumococcal polysaccharide vaccine 3 months after tube insertion. Blood samples were drawn at the first vaccination, at the time of TT placement, and 1 and 3 months after the second vaccination. Levels of IgA and IgG serum antibody against the 7-valent pneumococcal conjugate vaccine serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F were measured with enzyme-linked immunosorbent assays. All children were monitored for recurrence of OME for 6 months after spontaneous extrusion of the TTs. The overall recurrence rate of bilateral OME was 50%. Pneumo...Continue Reading
References
Apr 1, 1991·International Journal of Pediatric Otorhinolaryngology·C StenströmL Ingvarsson
Apr 1, 1990·Clinical Otolaryngology and Allied Sciences·G A ZielhuisP Van den Broek
Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·G A ZielhuisP van den Broek
Jun 1, 1984·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B Falk, B Magnuson
Mar 1, 1982·Pediatric Infectious Disease·G S GiebinkC T Le
Jun 1, 1995·Pediatric Research·L A SandersB J Zegers
Mar 1, 1996·Acta Oto-laryngologica·J JeroP Karma
Apr 1, 1997·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J Sadé, A Ar
Dec 16, 1998·The Pediatric Infectious Disease Journal·J L Paradise
May 13, 1999·International Journal of Pediatric Otorhinolaryngology·J EngelE Marres
May 17, 2000·Vaccine·M LipsitchG M Carlone
Jan 4, 2001·Vaccine·S K Obaro
Apr 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·N van HeerbeekG A Zielhuis
Jul 4, 2001·International Journal of Pediatric Otorhinolaryngology·U GokM Z Doymaz
Jul 24, 2001·Archives of Disease in Childhood·K E BennettI A Stewart
Mar 13, 2002·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·D P McCormickD L Johnson
Mar 29, 2002·Medical Hypotheses·M StraetemansG A Zielhuis
Oct 3, 2002·Pediatrics·Joanne E RobertsSusan A Zeisel
Jan 25, 2003·The Pediatric Infectious Disease Journal·Bruce FiremanPaula Ray
Feb 5, 2003·The Laryngoscope·Edith L G M TonnaerJo H A J Curfs
Jun 12, 2003·The Pediatric Infectious Disease Journal·Masja StraetemansGerhard A Zielhuis
Jul 5, 2003·Lancet·Reinier VeenhovenElisabeth Sanders
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Terhi KilpiUNKNOWN Finnish Otitis Media Study Group
Nov 5, 2003·International Journal of Pediatric Otorhinolaryngology·M StraetemansT Kilpi
Nov 26, 2003·The Journal of Infectious Diseases·M Catherine McEllistremEllen R Wald
Aug 6, 2004·The Pediatric Infectious Disease Journal·Arto A I PalmuTerhi M Kilpi
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Reinier H VeenhovenElisabeth A M Sanders
Citations
Jun 7, 2012·The Pediatric Infectious Disease Journal·Kim StolPeter W M Hermans
Nov 1, 2006·International Journal of Clinical Practice·P J Rees
Sep 8, 2006·Drugs·Ellen M Mandel, Margaretha L Casselbrant
Feb 12, 2014·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jochen Autschbach
Jun 19, 2013·Medical Microbiology and Immunology·Jeroen D LangereisPeter W M Hermans
Jun 25, 2014·International Journal of Pediatric Otorhinolaryngology·Joseph E KerschnerNikki Johnston
Mar 6, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Aly M N El-MakhzangyAmal A Hegazy
Jan 2, 2007·European Journal of Pediatrics·Thuy-My LeAnne G M Schilder
Oct 7, 2009·Expert Review of Vaccines·Markus Rose, Stefan Zielen
Sep 23, 2006·Expert Review of Vaccines·Allan W Cripps, Diana C Otczyk
Nov 5, 2008·Expert Review of Vaccines·Ener Cagri Dinleyici, Zeynel Abidin Yargic
Nov 6, 2007·The Journal of Infection·Craig Williams, Robert Masterton
Feb 3, 2007·Vaccine·Froukje Oosterhuis-KafejaPierre Van Damme
May 19, 2009·Vaccine·Gail L RodgersRon Dagan
Feb 2, 2013·International Journal of Pediatric Otorhinolaryngology·Kim StolPeter W M Hermans
Sep 15, 2012·Clinical and Experimental Otorhinolaryngology·Mukesh Kumar YadavJae-Jun Song
Apr 3, 2016·The Lancet Infectious Diseases·Ron DaganRobert Cohen
Mar 10, 2018·The Laryngoscope·Anita JeyakumarBrian J McKinnon
Aug 20, 2019·Human Vaccines & Immunotherapeutics·Ahmet SoysalMetin Karaböcüoğlu
Jul 28, 2010·Pediatrics·Lorry G RubinUNKNOWN Committee on Infectious Diseases and Section on Otolaryngology-Head and Neck Surgery