Effect of Combined Treatment With Folic Acid, Vitamin B6 , and Vitamin B12 on Plasma Biomarkers of Inflammation and Endothelial Dysfunction in Women

Journal of the American Heart Association
William G ChristenJoAnn E Manson

Abstract

The aim of this study was to determine whether reducing plasma homocysteine concentrations with long-term, combined treatment with folic acid, vitamin B6, and vitamin B12 alters plasma biomarkers of inflammation and endothelial dysfunction in women at increased risk of cardiovascular disease. We conducted a blood substudy of 300 treatment-adherent participants (150 in the active treatment group, 150 in the placebo group) in the WAFACS (Women's Antioxidant and Folic Acid Cardiovascular Study), a randomized, double-blind, placebo-controlled trial testing a daily combination of folic acid (2.5 mg), vitamin B6 (50 mg), vitamin B12 (1 mg), or matching placebo, in cardiovascular disease prevention among women at increased risk of cardiovascular disease. Plasma concentration of 3 biomarkers of inflammation (C-reactive protein, interleukin-6, and fibrinogen) and a biomarker of endothelial dysfunction (intercellular adhesion molecule 1) were measured at baseline and at the end of treatment and follow-up. After 7.3 years of combined treatment with folic acid, vitamin B6, and vitamin B12, homocysteine concentrations were reduced by 18% in the active treatment group as compared with the placebo group (P<0.001). However, there was no differ...Continue Reading

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Citations

Dec 19, 2018·Nutrients·Jeffrey L EbersoleArpita Basu
Oct 3, 2019·European Journal of Clinical Nutrition·Xiaodan BaoBaochang He
Dec 14, 2018·International Journal of Molecular Sciences·Rosa CasasEmilio Sacanella
Feb 19, 2020·Current Cardiology Reports·David Perez InglesHernando Garcia
May 10, 2019·Frontiers in Immunology·Ana María Ruiz-LeónRosa Casas
Nov 13, 2020·Frontiers in Pharmacology·Md Farhad HossainMohamed M Abdel-Daim

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Methods Mentioned

BETA
blood collection
ELISA
hormone replacement therapy

Software Mentioned

SAS

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