Effect of Commiphora molmol (oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice

The American Journal of Chinese Medicine
M M al-HarbiA H Shah

Abstract

The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C.molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.

Citations

Apr 9, 2005·Journal of Ethnopharmacology·Tawfeq Al-HowirinySyed Rafatullah
Jun 8, 2001·Journal of Ethnopharmacology·R M RaoA H Shah
Jan 1, 1997·Journal of Ethnopharmacology·M M al-HarbiA H Shah
Jan 26, 2006·Basic & Clinical Pharmacology & Toxicology·Ibrahim M El-AshmawyOsama M Salama
Aug 10, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Min-Sun KimSung-Joo Park
Jul 26, 2016·Experimental and Therapeutic Medicine·Amal Jamil FataniSalim Salih Al-Rejaie
Jan 31, 2020·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Ali S AlqahtaniPerwez Alam
Oct 6, 2021·Drug and Chemical Toxicology·Amine Hafis Abdelsalam, Hasan Basri Ila

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