Effect of comorbidity on urinary neopterin in patients with breast carcinoma

European Journal of Cancer Care
K MelicharováB Melichar

Abstract

Urinary neopterin is increased in less than 20% of patients with breast carcinoma. Moderately increased neopterin concentrations are also known to accompany comorbid conditions commonly observed in patients with breast carcinoma, for example, diabetes mellitus or complications of atherosclerosis. In the present study, we evaluated the effect of the presence of comorbid conditions on urinary neopterin. A trend for higher neopterin concentrations was observed in patients with most of the comorbid conditions, but significantly higher neopterin was observed only in patients aged 70 years or older and in a heterogeneous group of patients with comorbidity other than diabetes mellitus, thyroid disorder, hyperlipidaemia, cardiac disorder or other malignancy. Significantly higher neopterin levels were noted in patients with two or more comorbid conditions. In conclusion, present data demonstrate an association between systemic immune activation reflected in increased urinary neopterin concentrations and age or presence of comorbid diseases in patients with breast carcinoma. A cumulative effect was observed with the presence of two or more comorbid conditions resulting in significantly increased urinary neopterin. These observations shou...Continue Reading

References

Aug 1, 1991·Atherosclerosis·F TatzberH Esterbauer
Apr 1, 1994·Atherosclerosis·G WeissH Wachter
Jan 15, 1994·Annals of Internal Medicine·W A Satariano, D R Ragland
Sep 1, 1996·Annals of Epidemiology·R YancikB K Edwards
Mar 17, 2001·JAMA : the Journal of the American Medical Association·R YancikJ W Yates
Jan 25, 2003·American Journal of Epidemiology·Timothy L LashRebecca A Silliman
Aug 7, 2003·Journal of the National Cancer Institute·Julienne E BowerSteve W Cole
May 17, 2005·Lancet·Umberto VeronesiGiuseppe Viale
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B MelicharR S Freedman

❮ Previous
Next ❯

Citations

Dec 7, 2013·BMC Surgery·Alessandro CappellaniMassimiliano Berretta
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Carmela M Reichel, Ronald E See

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.