PMID: 36352Jan 1, 1979

Effect of complement inactivated rabbit antichick brain serum on thymic and splenic lymphocytes

International Archives of Allergy and Applied Immunology
J M Barnett, B Glick

Abstract

The effects on in vitro exposure of chicken thymic-dependent lymphocytes to complement inactivated rabbit antichick brain serum (RACB) previously absorbed with normal serum (ns) and kidney (k) [RACBns,k] was investigated. Spleen lymphocytes which normally initiate a 'graft vs. host' reaction give rise to much more intense reactions when treated with (RACB)ns,k. This may be due to increased antigenicity of the donor cell and/or stimulation of the donor T cell. Migration studies showed that chicken thymocytes are capable of in vitro migration which can be inhibited by exposure to (RACB)ns,k. Thymocytes pretreated with (RACB)ns,k were found to express factor(s) capable of inhibiting thymocyte migration. The correlation between lymphokines and increased splenomegaly was discussed.

Related Concepts

T-Lymphocyte
Cell Motility
Spleen
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Brain
Lymphoid Cells
Thymocyte Migration
Thymocyte
Immune Sera
Graft Vs Host Reaction

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