Effect of concanavalin A treatment on the allogeneic response of mice to challenge with P 815 mastocytoma: interleukin 2 treatment reverses concanavalin A suppression in vivo

Cellular Immunology
R D Ekstedt, D J Merdian

Abstract

Mice injected repeatedly with concanavalin A (Con A) prior to and following challenge with P 815 mastocytoma are suppressed in their cell-mediated cytotoxicity responses. Earlier studies showed that pretreatment of the animals with silica to affect macrophage (M phi) functions reversed the Con A suppression. In the present paper we have shown that peritoneal exudate cells (PEC) induced/activated by ip injection of Con A were able to transfer suppression to normal mice. Separation of the PEC populations into adherent and nonadherent cells abrogated their capacity to transfer suppression. It was further shown that Con A is not functioning in this in vivo system to block effector activity of cytotoxic cells on target cells, and PEC induced with Con A were not directly cytotoxic to target P 815 cells. Finally, we were able to show that the cytotoxicity response of Con A-suppressed mice could be enhanced by treatment with concentrated culture supernatants of normal mouse spleen cells, rich in interleukin 2 (IL 2) activity. Attempts to detect a recently described mouse serum inhibitor of IL 2 in normal or Con A-treated mice were unsuccessful and spleen cells from Con A-treated mice lost their capacity to generate IL 2 in vitro when c...Continue Reading

References

Aug 1, 1978·The Journal of Experimental Medicine·W PtakR K Gershon
Aug 1, 1972·Experimental Cell Research·C W Smith, A S Goldman
Mar 1, 1982·Immunobiology·H WagnerM Röllinghoff
Sep 11, 1980·The New England Journal of Medicine·C F NathanZ A Cohn
May 1, 1981·The Journal of Experimental Medicine·R Palacios, G Möller
Sep 1, 1982·Scandinavian Journal of Immunology·A BerettaG Möller

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Citations

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D P CerrettiP E Baker

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