PMID: 6975667Jan 1, 1981Paper

Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia

Cancer Chemotherapy and Pharmacology
P KlubesM A Meldon

Abstract

We examined the effect of concurrent SC infusion of calcium leucovorin (LV) on the action of 5-fluorouracil (FUra) against mouse L1210 leukemia implanted either SC or IP. Mice bearing the SC tumor treated with FUra (100 mg/kg, IP, day 1) plus infusion with either LV (11.5 mg . kg-1 . day-1, days 1-4), or 0.9% NaCl (days 1-4) resulted in an identical increase in median lifespan (ILS) of 28%. Similar experiments with FUra (100 mg/kg) plus LV infusion (115 mg . kg-1 . day-1) or FUra (200 mg/kg) plus LV infusion (115 mg . kg-1 . day-1) resulted in 50% and 59% ILS, respectively, which were not different from that obtained with the same doses of FUra plus 0.9% NaCl infusion. Mice bearing the IP tumor treated with FUra (100 mg/kg, IP, day 1) plus infusion with either LV (11.5 mg . kg-1 . day-1, days 1-4) or 0.9% NaCl (days 1-4) had an identical 56% ILS. Similar experiments with FUra (100 mg/kg) plus LV infusion (115 mg . kg-1 . day-1) or FUra (200 mg/kg) plus LV infusion (115 mg . kg-1 . day-1) resulted in 67% and 94% ILS, respectively, which were not different from those obtained with the same doses of FUra plus 0.9% NaCl infusion. Treatment of normal mice with FUra (200 mg/kg, IP, day 0) plus LV infusion (115 mg . kg-1 . day-1, days...Continue Reading

Citations

Jan 1, 1982·Cancer Chemotherapy and Pharmacology·P KlubesM A Meldon
Apr 15, 1994·Pharmacy World & Science : PWS·V W Ruiz van Haperen, G J Peters
Jan 1, 1984·Pharmacology & Therapeutics·F Valeriote, G Santelli
Jan 1, 1990·Pharmacology & Therapeutics·E MiniJ R Bertino
Dec 3, 1996·Cancer Letters·R L CysykA Monks
Aug 9, 2011·Clinical Colorectal Cancer·Amy S LucasRichard M Goldberg
Apr 15, 1994·Pharmacy World & Science : PWS·C L van der Wilt, G J Peters

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