Effect of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats

Thyroid : Official Journal of the American Thyroid Association
Ralf BiebingerMichael B Zimmermann

Abstract

Deficiencies of vitamin A and iodine are common in many developing countries. Vitamin A deficiency (VAD) may adversely affect thyroid metabolism. The study aim was to investigate the effects of concurrent vitamin A and iodine deficiencies on the thyroid-pituitary axis in rats. Weanling rats (n = 56) were fed diets deficient in vitamin A (VAD group), iodine (ID group), vitamin A and iodine (VAD + ID group), or sufficient in both vitamin A and iodine (control) for 30 days in a pair-fed design. Serum retinol (SR), thyroid hormones (FT(4), TT(4), FT(3), and TT(3)), serum thyrotropin (TSH), pituitary TSHbeta mRNA expression levels, and thyroid weights were determined at the end of the depletion period. Compared to the control and ID groups, SR concentrations were about 35% lower in the VAD and VAD + ID groups (p < 0.001), indicating moderate VA deficiency. Comparing the VAD and control groups, there were no significant differences in TSH, TSHbeta mRNA, thyroid weight, or thyroid hormone levels. Compared to the control group, serum TSH, TSHbeta mRNA, and thyroid weight were higher (p < 0.05), and FT4 and TT4 were lower (p < 0.001), in the VAD + ID and ID groups. Compared to the ID group, TSH, TSHbeta mRNA, and thyroid weight were hig...Continue Reading

References

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Citations

Jul 23, 2008·Bulletin of Experimental Biology and Medicine·L I Nadolnik, O I Valentyukevich
Jan 22, 2009·Journal of Nutritional Science and Vitaminology·Mansour SiavashRoya Kelishadi
May 16, 2018·Endocrinology·Brenda J MengelingJ David Furlow
Dec 31, 2008·International Journal of Food Sciences and Nutrition·Mahin HashemipourNavid Koleini
May 14, 2020·Nutrients·Salvatore BenvengaPoupak Fallahi

Related Concepts

Iodine
Pituitary Stalk
Thyroid Gland
Thyrotropin
Novothyral
Cytomel
Aquasol A
Rats, Holtzman

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