Effect of continuation treatment on residual symptoms in late-life depression: how well is "well"?

Depression and Anxiety
K S OpdykeD J Kupfer

Abstract

The objectives of this report were (1) to describe residual depressive symptoms in elderly patients during continuation therapy with combined nortriptyline and interpersonal psychotherapy; (2) to determine which symptoms were persistent; (3) to determine the clinical correlates of residual depressive symptoms; and (4) to document distinct response pattern clusters during combined continuation therapy. Box plot analyses of Hamilton depression scores and Global Assessment Scale scores, repeated twice monthly over 4 months, were conducted using data from 105 elderly depressives. Temporal trends in the data were examined via random regression analysis. Individual trajectories for each of the 105 patients were examined for patterns of response during continuation therapy. We observed a low mean Hamilton rating of 7 (SD = 2.3) at the start of continuation therapy and 5 (SD = 3.0) at the end. Both Hamilton and GAS scores showed modest but significant improvement over time. Hamilton variability was most apparent in symptoms of mood lowering, apathy, anxiety (psychological and somatic), feelings of guilt, anergia, insomnia, and loss of libido; other symptoms (retardation, agitation, hypochondriasis, loss of appetite, loss of weight, sui...Continue Reading

Citations

Aug 3, 2010·Pharmaceuticals·Joshua A Israel
Jun 21, 2011·Expert Opinion on Investigational Drugs·Jolanda PrinsS Mechiel Korte
Feb 28, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·H Silva, V Larach
Jun 17, 2003·Acta Psychiatrica Scandinavica·C GastóT Marcos
Dec 17, 2014·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Hyun-Ghang JeongSook-Haeng Joe
Apr 29, 2006·Journal of Psychopharmacology·Maurizio Fava
Nov 30, 2005·International Journal of Geriatric Psychiatry·Celia F HybelsK Ranga Rama Krishnan
Aug 3, 2001·Drugs & Aging·C F ReynoldsB D Lebowitz
Jul 20, 2005·Journal of Clinical Psychopharmacology·David J Kupfer
Jun 24, 2021·Perspectives in Psychiatric Care·Darawan WongprommateNahathai Wongpakaran

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