Effect of continuous enhanced vagal tone on atrioventricular nodal and sinoatrial nodal function in humans

Circulation Research
R L PageE N Prystowsky

Abstract

A constant intravenous infusion of phenylephrine (0.74 +/- 0.41 micrograms/kg/min) was given to 10 patients to cause a continuous augmentation in reflex vagal tone. After the infusion, the diastolic blood pressure increased from 76 +/- 7 to 89 +/- 11 mm Hg (p less than 0.01). The sinus cycle length and atrial-His (AH) interval were measured, and incremental atrial pacing was performed before and during phenylephrine infusion until atrioventricular (AV) nodal block was achieved. For each patient, the AV nodal function curve (i.e., the AH interval plotted as a function of the atrial pacing cycle length) was compared during both the control state and phenylephrine infusion; the AH intervals during each condition at chosen short (AHS) and long (AHL) cycle lengths were compared. The sinus cycle length increased during phenylephrine infusion from 941 +/- 294 to 1,115 +/- 347 msec (p = 0.013). The AH interval during sinus rhythm was not significantly prolonged (77 versus 82 msec, p = NS). The shortest atrial pacing cycle length yielding 1:1 AV nodal conduction increased during phenylephrine infusion from 412 +/- 120 to 575 +/- 211 msec (p less than 0.01). Of note, the degree of sinus cycle length prolongation did not correlate with th...Continue Reading

References

Jun 1, 1979·Circulation Research·G ManciaR Perondi
Jan 1, 1978·Progress in Cardiovascular Diseases·J J GallagherA G Wallace
May 1, 1990·Pacing and Clinical Electrophysiology : PACE·M TalajicS Nattel
Jan 1, 1987·Pacing and Clinical Electrophysiology : PACE·A H Dougherty, G V Naccarelli
Jan 1, 1988·Journal of Clinical Pharmacology·E N Prystowsky
May 1, 1985·Journal of Molecular and Cellular Cardiology·Y TsujiA J Pappano
Apr 1, 1988·Current Problems in Cardiology·E N Prystowsky
Aug 1, 1986·The Journal of Clinical Investigation·D L EckbergD F Gardner
Aug 1, 1974·The American Journal of Physiology·W C Randall, J A Armour
Jul 1, 1968·Circulation Research·J MeridethG K Moe
Dec 1, 1968·The American Journal of Physiology·T N JamesE W Green
Oct 1, 1969·Journal of Applied Physiology·M N Levy, H Zieske
Jan 1, 1959·Circulation Research·P F CRANEFIELDA P DE CARVALHO
Nov 1, 1960·Circulation Research·S VARMAW B YOUMANS

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Citations

Sep 19, 2003·Journal of the American College of Cardiology·Eric N PrystowskyAndrew A Wolff
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Dan WichterleMarek Malik
Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·E N Prystowsky
Mar 31, 2005·The Japanese Journal of Physiology·Tomoko NakamotoHidehiko Komine
Jun 26, 2014·Journal of Medical Case Reports·Kamal ShemisaJudith A Mackall
Apr 24, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Youhua Zhang, Todor N Mazgalev
Mar 2, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tuomo NieminenMika Kähönen
Mar 25, 2008·Progress in Biophysics and Molecular Biology·Flavia RavelliMarcello Disertori
Sep 2, 2017·Paediatric Drugs·Chalese Richardson, Eric S Silver
Jul 30, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yi-Ching Su, Chun-Hsien Hsu
Jul 11, 2009·Physiological Measurement·R CervigónF Castells
Nov 22, 2008·Journal of Applied Physiology·Michela MasèFlavia Ravelli

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