PMID: 9551851Apr 29, 1998Paper

Effect of continuous melatonin infusions on steady-state plasma melatonin levels in rats under near physiological conditions

Journal of Pineal Research
G HuetherRudiger Hardeland

Abstract

It was the aim of this study to measure the actual amount of melatonin required for elevating the circulating hormone from low daytime levels to the 10-fold higher nocturnal steady-state concentrations in rats. For this purpose, escalating doses of melatonin were continuously infused into the right jugular vein and blood samples were repeatedly drawn from the left jugular vein for a period of 2 hr in freely moving catheterized rats. In order to achieve an about 10-fold elevation of the plasma melatonin concentration, 500 ng melatonin/hr had to be infused, i.e., about 300 times the normal nocturnal melatonin content of the pineal. Infusions of up to 61 ng melatonin/hr (equivalent to the melatonin content of 40 pineals at darkness) failed to cause a significant rise of the low daytime steady-state concentrations in the blood. If the dose of 500 ng melatonin/h was infused at night, a less-pronounced rise of the blood levels was observed, as compared to that caused by the infusion of the same dose during daytime. No differences were found in the rate of metabolism between daytime and nighttime. The results of this study indicate 1) that the low basal concentrations of melatonin in the blood are not affected by an increased melatoni...Continue Reading

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Citations

Feb 28, 2001·Neuroscience Letters·F DragoF Foti
Sep 6, 2002·Journal of Veterinary Pharmacology and Therapeutics·N SimonB Bruguerolle
Jul 23, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuyan HanGianfranco Alpini
Oct 26, 2011·World Journal of Gastroenterology : WJG·Chun-Qiu ChenMartin Storr
Feb 21, 2014·Cellular and Molecular Life Sciences : CMLS·Darío Acuña-CastroviejoRussel J Reiter
Feb 14, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·José L Muñoz-PérezJesús M Míguez
Aug 4, 2005·Upsala Journal of Medical Sciences·Markus Sjöblom
Jul 22, 2008·Journal of Pineal Research·Hülya Cevik Aras, Jörgen Ekström
Nov 9, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B PoeggelerF Halberg
Nov 1, 2015·Bulletin of Experimental Biology and Medicine·A V MorozovV Kh Khavinson
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·J B FourtillanJ Girault

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