Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome

Chest
Kazuyuki KobayashiMitsuhiro Yokoyama

Abstract

Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis. CD40-CD40 ligand interaction promotes several proinflammatory mediators and plays a pivotal role in the various stages of atherosclerotic diseases. The present study examines whether CD40 ligation contributes to outcomes in patients with OSAS. The study population comprised OSAS patients with an apnea hypopnea index (AHI) > or = 30 (n = 35) and control subjects (AHI < 5; n = 16). We measured serum levels of soluble CD40 ligand (sCD40L), tumor necrosis factor (TNF)-alpha, and hypersensitive C-reactive protein (hsCRP) before and after nasal continuous positive airway pressure (nCPAP) therapy for 3 months. Baseline levels of sCD40L were significantly higher in patients with OSAS (6.93 +/- 4.64 ng/mL) [mean +/- SD] than in control subjects (3.43 +/- 2.11 ng/mL, p < 0.01). Baseline levels of sCD40L positively correlated with TNF-alpha but not with hsCRP. The elevation of sCD40L was improved for 1 night after nCPAP therapy (3.83 +/- 2.78 ng/mL, p < 0.001). Even though patients with severe OSAS did not receive any other medication to control atherosclerotic risk factors for 3 months, nCPAP was continued to reduce the levels of sCD40L. The presen...Continue Reading

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Citations

Jan 17, 2009·Sleep & Breathing = Schlaf & Atmung·Herbert J YueJoel E Dimsdale
Mar 4, 2010·Sleep & Breathing = Schlaf & Atmung·Alessandra QuercioliFabrizio Montecucco
Jul 14, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Li-Ang LeeHsueh-Yu Li
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Jul 20, 2014·Clinics in Geriatric Medicine·Nalaka S Gooneratne, Michael V Vitiello
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Aug 4, 2009·Sleep Medicine·David Gozal
Mar 3, 2009·Progress in Cardiovascular Diseases·Allan I Pack, Thorarinn Gislason
May 10, 2008·The Journal of Allergy and Clinical Immunology·Reena Mehra, Susan Redline
Sep 20, 2011·Journal of Sleep Research·Bernabe Jurado-GamezDavid Gozal
Jan 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Yasuhiko NakagawaTohru Funahashi
Feb 10, 2020·Sleep & Breathing = Schlaf & Atmung·Ana C KriegerJoan H F Drosopoulos
Jul 25, 2021·Journal of Clinical Medicine·Cindy ZolotoffNathalie Perek

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