PMID: 15230482Jul 3, 2004Paper

Effect of contrast enhancement on measurement of carotid artery intimal medial thickness

Vascular Medicine
James E MaciochSteven B Feinstein

Abstract

Previous studies have used standard B-mode ultrasound to quantify the aggregate mean intimal medial thickness (IMT) of the near and far wall of the common carotid artery (CCA). Many investigators have had difficulty in accurately evaluating the near wall IMT secondary to difficulty in discerning the vessel lumen and intima. The purpose of this study is to determine the effect of contrast enhanced ultrasound on IMT measurement when compared with non-enhanced images. Twenty-six patients who had standard carotid ultrasounds completed over a 6-month period were evaluated, with 24 imaged by the same sonographer. Five to six measurements of the near and far walls were obtained over a 1 cm distance, beginning and ending 0.5 cm and 1.5 cm proximal to the carotid bifurcation. The measurements were made with and without the contrast agent Optison (perflutren protein type-A microspheres), which was given as an i.v. bolus (0.5-0.7 cc). Of those imaged by the same sonographer, 40 carotid arteries were examined and a total of 867 measurements were obtained. A total of 10% of the carotid ultrasounds were restudied approximately 1 month after the initial interpretation to assess observer accuracy. The near wall CCA mean (SD) IMT was 0.075 (0.0...Continue Reading

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Citations

Jan 28, 2012·Current Atherosclerosis Reports·Smita I Negi, Vijay Nambi
Jun 17, 2014·Echocardiography·Uchechukwu K A SampsonSteve B Feinstein
Feb 27, 2007·Vascular Health and Risk Management·Helen A LaneJ Stephen Davies
Aug 19, 2008·Current Atherosclerosis Reports·Blai Coll, Steven B Feinstein
Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V Pokrovsky, D F Beloyartsev
Nov 19, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Steven B FeinsteinKai Thomenius
Dec 25, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Li XiongYun Zhang
Sep 2, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Marco MagnoniAttilio Maseri
Jul 25, 2008·Nature Clinical Practice. Cardiovascular Medicine·Juan F Granada, Steven B Feinstein

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