Effect of contrast media on in vitro bleeding time: assessment by a hollow fiber instrument

Academic Radiology
L G MeltonD A Gabriel

Abstract

We used a global screening device that operates under physiologic flow conditions to monitor the effects of ionic and nonionic contrast media (CM) on hemostasis. This flow dynamic technique perfuses unanticoagulated whole blood through a hollow fiber. A leak in the fiber is created by a precision needle, and the resulting pressure fluctuations within the fiber are monitored to examine the ability of the hemostatic system to close the leak by forming a stable platelet plug. Both ionic and nonionic CM (25% CM/blood, v/v) were shown to lengthen the mean in vitro bleeding times (IVBTs) compared with normal blood. Ionic CM (ioxaglate and diatrizoate) consistently produced IVBTs longer than 30 min. The nonionic CM iopamidol, iohexol, and ioversol gave mean IVBTs of 16.43, 17.63, and 19.84 min, respectively. Of the three nonionic CM tested, iopamidol had the greatest probability (31%) of producing an IVBT in the normal range, with probabilities of 5% and 7% for iohexol and ioversol, respectively. Thus, iopamidol offered the least anticoagulant effect among the ionic and nonionic CM we studied.

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B B WekslerE A Jaffe
Apr 1, 1979·Prostaglandins·J R Weeks, L D Compton
Jan 1, 1979·Thrombosis Research·C Kettner, E Shaw
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Citations

Jul 1, 2003·Current Therapeutic Research, Clinical and Experimental·Yurdanur KilinçEsmeray Acartürk
Jan 6, 2006·European Radiology·Peter AspelinUNKNOWN Members of the Contrast Media Safety Committee of the European Society of Urogenital Radiology (ESUR)
May 1, 1996·Academic Radiology·L G MeltonD A Gabriel
Apr 12, 2012·Korean Circulation Journal·Min Seok OhTae Ho Kim

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