PMID: 9543225May 30, 1998Paper

Effect of cooling on vascular smooth muscle response to endothelin-1 in human and rat veins

International Angiology : a Journal of the International Union of Angiology
M BodelssonB Arneklo-Nobin

Abstract

The plasma level of endothelin-1 is locally increased during cooling but the net vasoconstrictor effect will be dependent on temperature effects on the vascular smooth muscle reactivity in response to the polypeptide. The aim of this study was to investigate the effect of cooling on the vascular smooth muscle response to endothelin-1 in human and rat veins. Registration of vascular smooth muscle activity in vitro in vessel preparations from normal subjects. Laboratory. PATIENTS AND ANIMALS: Superficial hand veins from 14 patients undergoing hand surgery and external jugular veins from 14 rats. Effects of endothelin-1, after denudation of the endothelium and during cooling, were compared with controls without these interventions. At 37 degrees C, endothelin-1 induced a concentration-dependent contraction in the human hand and rat jugular veins. The sensitivity to endothelin-1 was enhanced in segments without endothelium. At 37 degrees C, no relaxation in response to endothelin-1 was observed. Cooling to 10 degrees C did not alter precontraction achieved by endothelin-1 at 37 degrees C in the human hand veins, while it depressed the precontraction in the rat jugular vein. The effect of cold was reversible. Removal of the endothel...Continue Reading

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