PMID: 166934Mar 15, 1975

Effect of cordycepin on the replication of type-c RNA tumor viruses

International Journal of Cancer. Journal International Du Cancer
L S RichardsonA M Wu

Abstract

Cordycepin (3'-deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (Wu et al., 1972). We now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. Cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since viral production was greatly reduced (seven- to 35-fold) with 5-10 mug/ml of cordycepin while viral transformation was only slightly inhibited (two-fold reduction in focus-forming units) with the same concentration of cordycepin. Inhibition of viral production is most effective if the compound is present during the first 24 h after injection.

References

Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A M WuR C Gallo
Nov 1, 1971·The Journal of General Virology·S A Aaronson, C A Weaver
Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·M Green, M Cartas
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PhilipsonJ E Darnell
Oct 1, 1966·Journal of Bacteriology· Huu Duc-NguyenR F Zeigel

Citations

Jan 1, 1980·Pharmacology & Therapeutics·W M Shannon, F M Schabel
Jan 1, 1984·Journal of Medical Virology·M ClementiL Calegari
Jun 7, 2011·Journal of Liquid Chromatography & Related Technologies·Licai ZhuYoichiro Ito
Jun 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peng QinDengXue Lu
Jul 15, 1977·International Journal of Cancer. Journal International Du Cancer·M S ReitzR C Gallo
Oct 3, 2018·Current Medicinal Chemistry·Md Asaduzzaman Khan, Mousumi Tania

Related Concepts

Tumor Antigens
Neoplastic Cell Transformation
Microcytotoxicity Test
Deoxyadenosines
Depression, Chemical
Mice, Inbred BALB C
Moloney Leukemia Virus
Rauscher Virus
Retroviridae
Virus Replication

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