Effect of cordycepin on the replication of western equine encephalitis virus

Archives of Virology
K Hashimoto, B Simizu

Abstract

Cordycepin (3'-deoxyadenosine) inhibited viral RNA synthesis in the replication of western equine encephalitis virus, thereby causing a reduction of virus production. The rate of inhibition of viral RNA synthesis was dependent on drug concentration and the period of treatment with the drug. These results suggest that the virus RNA synthesizing system is sensitive to the drug.

References

Aug 1, 1976·Japanese Journal of Medical Science & Biology·K Hashimoto, B Simizu
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R E Johnston, H R Bose
Jul 5, 1973·Journal of Molecular Biology·M Soria, A S Huang
May 1, 1974·Journal of Virology·E Ehrenfeld
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S PenmanM Penman

Related Concepts

Ac-De
Deoxyadenosines
Encephalitis Virus, Western Equine
RNA, Viral
Virus Replication

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