PMID: 8985805Dec 1, 1996Paper

Effect of coronary perfusion of heptanol on conduction and ventricular arrhythmias in infarcted canine myocardium

Journal of Cardiovascular Electrophysiology
D J CallansJ F Spear

Abstract

Abnormal cellular coupling is a major constituent of the slow, dissociated conduction that supports ventricular tachycardia (VT) following myocardial infarction. Agents that modulate cellular coupling may exert either proarrhythmic or antiarrhythmic effects. The effects of modulating cellular coupling on conduction and susceptibility to inducible VT were studied in 11 dogs with healed left anterior descending (LAD) infarction. The LAD circulation was isolated and supplied with arterial blood via a constant-flow bypass system. Localized intracoronary infusion of heptanol, an agent with relatively specific effects on intracellular coupling, was performed using this bypass system. Heptanol produced dose-dependent changes in cardiac conduction, assessed by delayed local activation times in sinus rhythm (0.5 mM: 11.9% +/- 11.0% change, P = 0.005; 1.0 mM: 45.8% +/- 25.5% change, P = 0.0004) and slowed conduction velocity both transverse and longitudinal to fiber orientation. Sustained VT was not induced in any of the control animals. During infusion of 0.5 mM heptanol, uniform sustained VT was inducible in 4 of 11 animals (P = 0.027). During infusion of 1.0 mM heptanol, sustained VT was induced in only 1 of 9 animals. In the canine m...Continue Reading

References

Apr 1, 1991·Circulation Research·W L Nelson, J C Makielski
Jan 1, 1990·Circulation Research·J F SpearE N Moore
Oct 1, 1989·Pflügers Archiv : European journal of physiology·A Rüdisüli, R Weingart
Nov 1, 1985·The American Journal of Physiology·R L WhiteM V Bennett

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