Effect of coronary stenotic lesions on regional myocardial blood flow at rest

Circulation
A B NicholsP D Esser

Abstract

To determine the effect of atherosclerotic coronary lesions on myocardial blood flow in patients at rest, regional myocardial blood flow was measured distal to stenotic lesions in 29 patients with isolated proximal lesions of the left anterior descending artery. Severity of coronary stenosis was measured by computer-assisted cinevideodensitometric analysis of digitized coronary arteriograms. Regional myocardial blood flow was measured from the clearance rate of intracoronary 133Xe injected into the left main coronary artery and recorded with a multicrystal scintillation camera. In 21 patients with stenotic lesions ranging from 19% to 84% area reduction, distal regional myocardial blood flow was normal. In all eight patients with reduced regional myocardial blood flow distal to left anterior descending lesions, the minimum area of each stenotic lesion was less 0.80 mm2 (mean 0.34 +/- 0.2 mm2), minimum calculated diameter was less than 1 mm (mean 0.59 +/- 0.3 mm), and percent stenosis, based on the reduction in cross-sectional area, was greater than 85% (mean 94 +/- 4%). For all patients, distal flow, expressed as a fraction of normal flow, correlated with the lesion cross-sectional area (r = .84), minimum luminal diameter (r = ....Continue Reading

References

May 1, 1978·The American Journal of Cardiology·R L FeldmanC R Conti
Jan 1, 1976·Journal of Biomechanics·B D Seeley, D F Young
Jul 1, 1975·The Journal of Surgical Research·A FuruseV L Gott
Jul 1, 1975·IEEE Transactions on Bio-medical Engineering·S E Logan
Jul 1, 1973·Journal of Biomechanics·D F Young, F Y Tsai
Sep 1, 1973·Journal of Biomechanics·D F Young, F Y Tsai
Jul 1, 1974·Annals of Surgery·R Berguer, N H Hwang
Oct 1, 1972·The Journal of Clinical Investigation·S C SmithJ J Collins

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Citations

Sep 1, 1992·Computer Methods and Programs in Biomedicine·O Smedby
Jul 1, 1988·Journal of the American College of Cardiology·A B NicholsD K Blood
Apr 1, 1989·Journal of the American College of Cardiology·A B NicholsE R Powers
Mar 1, 1995·Journal of the American College of Cardiology·C MarcassaP Giannuzzi
May 1, 1988·Journal of the American College of Cardiology·D W MyearsS R Bergmann
Jan 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·G Sambuceti, O Parodi
Sep 30, 1992·Annals of the New York Academy of Sciences·J W ParkK W Heinrich
Dec 6, 2003·Medical Physics·Hsien-Chih WuJohn D Carroll
Oct 11, 2002·IEEE Transactions on Medical Imaging·S Y James ChenJohn C Messenger
Sep 1, 1987·Catheterization and Cardiovascular Diagnosis·K H SilverA B Nichols
Mar 1, 1987·Catheterization and Cardiovascular Diagnosis·R K MylerM C Murphy

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