PMID: 3765368Sep 1, 1986Paper

Effect of corticosteroid on porcine leukocytes: age-related effects of corticosteroid inhibition on porcine lymphocyte responses to mitogens

Veterinary Immunology and Immunopathology
W C Yang, R D Schultz

Abstract

The effects of prednisolone sodium succinate on the responses of porcine lymphocytes to phytohemagglutinin (PHA) and pokeweed mitogen (PWM) were investigated. Sensitivity of peripheral blood lymphocytes (PBL) to the synthetic glucocorticoid, prednisolone, was related to age of the lymphocyte donor. The greatest sensitivity was found in PBL from animals less than one week old; PBL from animals between 2 to 4 months retained some glucocorticoid sensitive cells; whereas, PBL from animals older than 6 months were exceptionally resistant to steroid. Similar age-associated sensitivities were found for lymphocytes from lymph node, spleen and thymus. Significant differential sensitivities among the various lymphoid organs were found with the thymic lymphocyte possessing the greatest sensitivity to steroid and the PBL lymph node and splenic lymphocytes possessing the highest resistance to the suppressive effects of steroid. The age related differences in sensitivity to steroid did not appear to be caused by differences in the number of steroid receptors because lymphocytes from susceptible and resistant animals had similar numbers of receptors. The results suggest that the age related sensitivity may be associated with a higher percenta...Continue Reading

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·J E Parrillo, A S Fauci
Aug 1, 1979·Cellular Immunology·D DuvalJ P Dausse
Jun 1, 1978·The Australian Journal of Experimental Biology and Medical Science·A Mansour, D S Nelson
Feb 1, 1976·Experimental Cell Research·H Blomgren, B Andersson
Feb 1, 1974·Metabolism: Clinical and Experimental·E B Thompson, M E Lippman
Jan 1, 1973·Immunological Communications·J H Kaplan, A F Razzano
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Jan 1, 1980·Annual Review of Physiology·B S Katzenellenbogen

❮ Previous
Next ❯

Citations

Apr 1, 1987·Veterinary Immunology and Immunopathology·W C YangJ S Spano
Jan 15, 1992·Veterinary Immunology and Immunopathology·G Oldham, C J Howard
Oct 14, 2003·Journal of Comparative Pathology·K KawashimaY Murakami
Jun 20, 2002·Veterinary Immunology and Immunopathology·K A Skjolaas, J E Minton
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·D CouretE Merlot
Mar 1, 1991·Journal of Veterinary Internal Medicine·L A Cohn
Aug 19, 2010·Pediatric Research·Margret TuchschererArmin Tuchscherer
Dec 23, 2011·Vaccine·Douglas C Hodgins, Patricia E Shewen
Feb 26, 2015·Acta Cirúrgica Brasileira·Juan Carlos LlanosAlexandre Bakonyi Neto
Oct 1, 1988·European Journal of Immunology·O P Chilson, A E Kelly-Chilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.