Effect of corticosterone on gene expression of feed intake regulatory peptides in laying hens

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Lei LiuH Lin

Abstract

The present study was conducted to explore the effects of corticosterone (CORT) on the regulation of appetite-associated genes in laying hens. Forty eight laying hens were randomly divided into two groups: one received subcutaneous injection of CORT (2mg/kg body weight, CORT-exposed) and the other received sham-treatment (Control). Treatment of hens with CORT stimulated an increase (P<0.05) in plasma CORT, glucose, uric acid (UA), insulin, cholesterol (Chol) and triiodothyronine (T(3)), but the concentrations of plasma non-esterified fatty acids (NEFA) and triacylglycerol (TG) were decreased (P<0.05). CORT treatment had no significant effect (P>0.05) on the mRNA levels of neuropeptide Y (NPY), corticotropin-releasing hormone (CRH), melanocortin receptor 4 and 5 (MCR-4 and MCR-5) and cholecystokinin (CCK) in the hypothalamus when compared with control hens. However, the expression of pro-opiomelanocortin (POMC), agouti-related protein (AgRP) and melanocortin recepter 1 (MCR-1) were significantly (P<0.05) suppressed while the mRNA levels of ghrelin and cocaine-and amphetamine-regulated transcript (CART) were significantly upregulated (P<0.05) in CORT-treated hens. Treatment of laying hens with CORT had no significant (P>0.05) eff...Continue Reading

References

Jul 1, 1995·British Poultry Science·M Covasa, J M Forbes
Sep 1, 1997·Physiology & Behavior·M ChavezS C Woods
Apr 21, 1999·Clinical Science·R C Andrews, B R Walker
Aug 31, 2000·Biochemical and Biophysical Research Communications·K TsutsuiP J Sharp
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 24, 2002·European Journal of Pharmacology·Ei-suke SaitoMitsuhiro Furuse
Dec 12, 2002·The Journal of Experimental Zoology·W J KuenzelR Teruyama
Jan 22, 2003·Neuroscience Letters·Tetsuya TachibanaMitsuhiro Furuse
Feb 28, 2003·General and Comparative Endocrinology·Katrina G Salvante, Tony D Williams
Jun 24, 2003·Poultry Science·A B Webster
Jun 18, 2004·Biology of Reproduction·I RozenboimM E El Halawani
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ikuko SatoYutaka Oiso
Jun 19, 2007·Poultry Science·M P Richards, M Proszkowiec-Weglarz
Dec 7, 2007·Diabetes/metabolism Research and Reviews·Michela NovelliPellegrino Masiello
Apr 25, 2008·The Journal of Endocrinology·David P MacfarlaneBrian R Walker
Dec 6, 2008·General and Comparative Endocrinology·Hiroyuki KaiyaKenji Kangawa
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mardi S ByerlyTom E Porter
Apr 28, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yuanli CaiHai Lin
Jun 2, 2009·Frontiers in Bioscience (Scholar Edition)·Serge Luquet, Christophe Magnan

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Citations

Jan 15, 2015·General and Comparative Endocrinology·Timothy Boswell, Ian C Dunn
May 1, 2015·Asian-Australasian Journal of Animal Sciences·Yeon-Hwa KimYang-Ho Choi
Jul 31, 2020·Animals : an Open Access Journal From MDPI·Wen Yang ChuangTzu-Tai Lee
Dec 2, 2014·Journal of Agricultural and Food Chemistry·Jimin Kim, Yang-Ho Choi

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