PMID: 6148092Oct 1, 1984Paper

Effect of Corwin (ICI 118587) on resting and exercise heart rate and exercise tolerance in digitalised patients with chronic atrial fibrillation

British Heart Journal
A O MolajoD H Bennett


The effect of Corwin, a new oral beta, partial agonist, on the ventricular response to atrial fibrillation was studied in digitalised patients during 24 hour ambulatory electrocardiography and during exercise on a treadmill in a double blind placebo controlled crossover trial. Corwin reduced the maximum heart rate during exercise from 162(16) beats/min to 120(9) beats/min and reduced the peak heart rate during ambulatory electrocardiography from 113(11) to 90(6) beats/min consistent with a beta adrenoreceptor antagonist action at higher levels of sympathetic nervous system activity. Minimum heart rate during ambulatory electrocardiography was increased from 62(5) to 70(5) beats/min indicating that at lower levels of sympathetic activity the drug acts as a beta agonist. The drug increased exercise tolerance significantly. Serum digoxin concentrations were not affected by the drug. Thus Corwin appears to be effective in stabilising heart rate during atrial fibrillation both at rest and during exercise in digitalised patients.


Jun 24, 1986·European Journal of Pharmacology·E Vigholt Sørensen, F Nielsen-Kudsk
Mar 1, 1988·Journal of the American College of Cardiology·J E AtwoodV Froelicher
Aug 1, 1987·Journal of the American College of Cardiology·J E AtwoodV F Froelicher
Aug 1, 1990·British Journal of Clinical Pharmacology·D G Waller
Sep 1, 1991·British Journal of Clinical Pharmacology·K S Channer
Jan 1, 1994·British Journal of Clinical Pharmacology·K S ChannerJ R Rees
Nov 24, 2007·BMJ : British Medical Journal·Theodora Nikolaidou, Kevin S Channer
Nov 1, 1986·British Heart Journal·F L TseuA F Mackintosh
Oct 1, 1993·British Heart Journal·J C Cowan
Jan 1, 1986·European Journal of Clinical Pharmacology·L BarriosH de Geest
Mar 25, 1993·The American Journal of Cardiology·J M Cruickshank
Jan 1, 1992·International Journal of Cardiology·M TangøJ Trap-Jensen
Nov 15, 1990·The American Journal of Cardiology·C K WongC H Cheng
May 1, 1993·American Heart Journal·K UeshimaV F Froelicher

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