PMID: 759377Jan 15, 1979

Effect of Corynebacterium parvum on hemopoietic stem-cell kinetics

International Journal of Cancer. Journal International Du Cancer
G EliopoulosB Halpern


The intravenous administration of 548 microgram of killed Corynebacterium parvum (C. parvum) into C57BL mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (CFUs) as early as 12 h after the injection of the bacterium. This decrease persisted in varying degrees for 3 weeks. After an initial fall at 24 h, the splenic CFUs exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. A significant rise in the number of circulating CFUs, reaching a first peak at 2 h and a second one on the fifth day, was also observed. The proliferative status of femoral CFUs was increased at 48 and 72 h, while that of splenic CFUs presented a significant increase only 48 h after the injection of C. parvum. The sequence of events which were observed in these experiments indicates that an accelerated migration of hemopoietic stem cells from bone marrow to spleen via the blood circulation has to take place.


Aug 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G EliopoulosB N Halpern


Jan 1, 1976·Cell and Tissue Kinetics·S K Lahiri
Feb 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·N V DimitrovB Halpern
Mar 1, 1972·Cell and Tissue Kinetics·F C MonetteF Stohlman
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·K A RickardF Stohlman
Jun 25, 1959·Annals of the New York Academy of Sciences·C M AMBRUS, J L AMBRUS

Related Concepts

Collema parvum
Cryptosporidium parvum
Colony-Forming Units, Hematopoietic
Bone Marrow
Chrysosporium parvum
Coitocaecum parvum
Cell Division Phases
Cullen parvum
Cell Density

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