Effect of cosmetic ingredients as anticellulite agents: synergistic action of actives with in vitro and in vivo efficacy

Journal of Cosmetic Dermatology
Tamara Al-BaderAurelie Laloeuf

Abstract

The pathophysiology of cellulite involves changes in the subcutaneous adipose layer and the extracellular matrix (ECM) that supports it together with overlying dermal layer. Cellular mechanisms governing cellulite are not fully understood. However, it is accepted that changes include enhanced lipogenesis, decreased lipolysis, and increased lipid storage within the adipocytes as well as changes in the dermal architecture. In our studies the ability of cosmetic agents Furcellaria lumbricalis, Fucus vesiculosus, retinoid, conjugated linoleic acid (CLA), and a glaucine mixture to stimulate in vitro 1) lipolysis in human adipocytes and 2) production of pro-collagen I by fibroblasts was investigated in vitro. The ability of these ingredients to improve cellulite condition in vivo was also determined. Mature adipocytes and 'aged' fibroblasts were used for in vitro studies. The assessment of cellulite in vivo was performed by dermatological grading and ultrasound measurements. Mature adipocytes treated with combined actives resulted in a significant synergistic increase in free glycerol release. On "aged" fibroblasts, combined treatment of F. vesiculosus and F. lumbricalis stimulated pro-collagen I production. CLA increased pro-collage...Continue Reading

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Citations

Mar 8, 2013·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Doris HexselDaiane Hehn De Oliveira
Nov 11, 2014·Drug Development and Industrial Pharmacy·Hamed HamishehkarMaryam Kouhsoltani
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Jul 7, 2015·Journal of Cosmetic Dermatology·Irene ZeriniGiuseppe Nisi
May 6, 2015·American Journal of Clinical Dermatology·Stefanie LuebberdingNeil S Sadick
Mar 17, 2017·Journal of Cutaneous Medicine and Surgery·Sophia Colantonio, Jason K Rivers
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Jun 26, 2021·Tissue & Cell·Lydia SegallaAndrea Sbarbati
Aug 7, 2021·Pharmaceuticals·Ngamrayu NgamdokmaiKornkanok Ingkaninan

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