Effect of coumestrol on bone metabolism in organ culture

Biological & Pharmaceutical Bulletin
N Tsutsumi

Abstract

Coumestrol, a representative phytoestrogen, inhibited bone resorption-stimulating agent-induced bone resorption, whereas it did not inhibit basal bone resorption of cultured fetal rat limb bone. Coumestrol increased the calcium content of 9-d-old chick embryonic femurs in organ culture, indicating that this phytoestrogen stimulated bone-mineralizing activity. Therefore, coumestrol is a unique substance in that it inhibits bone resorption and, at the same time, stimulates bone mineralization. Coumestrol exhibited less estrogenic activity than 17 beta-estradiol as estimated by the increase in uterine weight of ovariectomized rats. As coumestrol has less estrogenic activity than 17 beta-estradiol, it may prove to be a more potent drug against bone diseases including osteoporosis.

Citations

Jul 9, 2011·The British Journal of Nutrition·Gunter G C KuhnleKay-Tee Khaw
Jul 26, 2011·The British Journal of Nutrition·Malihezaman MonsefiTahereh Talaei-Khozani
Oct 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·J A DodgeH U Bryant
Nov 15, 2000·Mayo Clinic Proceedings·A Vincent, L A Fitzpatrick
Jan 24, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xiao-tao WuJi-nan Wei
Jul 18, 2002·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·K SzkudelskaL Nogowski
Jan 1, 1997·Annual Review of Nutrition·M S Kurzer, X Xu
Oct 30, 2016·Journal of Natural Products·Jianfei ShengYong Zou
Nov 27, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L M Chiechi
Jun 1, 1999·Nutrition Research Reviews·J J AndersonS C Garne
Sep 19, 2003·Phytotherapy Research : PTR·Andreana L Ososki, Edward J Kennelly
Nov 23, 2006·Journal of Biomedical Materials Research. Part a·Jui-Sheng SunShiow-Yunn Sheu
Dec 25, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Edward W Carney, Carole A Kimmel
Mar 17, 2001·Environmental Health Perspectives·P L Whitten, H B Patisaul
Feb 7, 2003·European Journal of Clinical Nutrition·G JonesT M Greenaway
Apr 1, 1997·Annals of Medicine·H Adlercreutz, W Mazur
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickUNKNOWN American Association of Clinical Endocrinologists
Aug 26, 2003·The American Journal of Clinical Nutrition·Kenneth D R Setchell, Eva Lydeking-Olsen
Dec 2, 2020·European Journal of Medicinal Chemistry·Ankur Kumar TanwarVikas Jaitak
Apr 20, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yanbei TuChengwei He
Jun 29, 1999·Baillière's Clinical Endocrinology and Metabolism·J J Anderson, S C Garner
Mar 16, 2011·The Journal of Organic Chemistry·Lina TangKang Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.