PMID: 321444Mar 25, 1977Paper

Effect of CrATP on the association of the reacting forms of yeast hexokinase.

The Journal of Biological Chemistry
B P Yip, F B Rudolph

Abstract

Reacting enzyme sedimentation studies have been performed with yeast hexokinase isozymes A and B in the presence and absence of chromium ATP at pH 6.75. Preincubation of either isozyme with CrATP causes a shift in the monomer-dimer equilibrium toward the monomeric form. The results are consistent with the observed increase in inhibition caused by CrATP (Danenberg, K.D., and Cleland, W.W. (1975) Biochemistry 14, 28-39) being due to a conformational change in the protein which causes a decrease in the association constant for the monomer.

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