PMID: 18708688Aug 19, 2008Paper

Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults

International Journal of Sport Nutrition and Exercise Metabolism
D G BurkeTim Ziegenfuss

Abstract

The purpose of this study was to compare changes in muscle insulin-like growth factor-I (IGF-I) content resulting from resistance-exercise training (RET) and creatine supplementation (CR). Male (n=24) and female (n=18) participants with minimal resistance-exercise-training experience (=1 year) who were participating in at least 30 min of structured physical activity (i.e., walking, jogging, cycling) 3-5 x/wk volunteered for the study. Participants were randomly assigned in blocks (gender) to supplement with creatine (CR: 0.25 g/kg lean-tissue mass for 7 days; 0.06 g/kg lean-tissue mass for 49 days; n=22, 12 males, 10 female) or isocaloric placebo (PL: n=20, 12 male, 8 female) and engage in a whole-body RET program for 8 wk. Eighteen participants were classified as vegetarian (lacto-ovo or vegan; CR: 5 male, 5 female; PL: 3 male, 5 female). Muscle biopsies (vastus lateralis) were taken before and after the intervention and analyzed for IGF-I using standard immunohistochemical procedures. Stained muscle cross-sections were examined microscopically and IGF-I content quantified using image-analysis software. Results showed that RET increased intramuscular IGF-I content by 67%, with greater accumulation from CR (+78%) than PL (+54%;...Continue Reading

Citations

Jul 24, 2012·Journal of the International Society of Sports Nutrition·Robert CooperAlfonso Jimenez
Mar 24, 2017·Sports Medicine·Eric S RawsonMark A Tarnopolsky
Aug 10, 2020·American Journal of Therapeutics·Yanbing WuLiLi Chen
Mar 19, 2014·European Journal of Applied Physiology·Matthew B CookeDarryn S Willoughby
Jul 1, 2015·Journal of the Royal Army Medical Corps·Konstantinos Havenetidis
Jan 19, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Eric S RawsonD Enette Larson-Meyer
May 1, 2020·International Journal of Environmental Research and Public Health·Mojtaba KavianiPhilip D Chilibeck
Jun 3, 2017·Journal of Applied Physiology·Marina Yazigi SolisBruno Gualano
Jun 5, 2018·American Journal of Physical Medicine & Rehabilitation·Dariush Sheikholeslami-Vatani, Hassan Faraji
Jan 4, 2019·European Journal of Nutrition·Pedro L ValenzuelaAlejandro Lucia
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Feb 27, 2021·Journal of Physiology and Biochemistry·Hersh NouriMohammad Raman Moloudi
Jun 3, 2021·Nutrients·Kylie K HarmonMatt S Stock
Jul 9, 2021·Current Sports Medicine Reports·Matthew HallKristofer Tupper

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