Effect of cross-linked chitosan iron (III) on vascular calcification in uremic rats

Experimental Biology and Medicine
Barbara Bruna Abreu de CastroHelady Sanders-Pinheiro

Abstract

Cross-linked chitosan iron (III) is a chitin-derived polymer with a chelating effect on phosphorus, but it is untested in vascular calcification. We evaluated this compound's ability to reduce hyperphosphatemia and its effect on vascular calcification in uremic rats using an adenine-based, phosphorus-rich diet for seven weeks. We used a control group to characterize the uremia. Uremic rats were divided according the treatment into chronic kidney disease, CKD-Ch-Fe(III)CL (CKD-Ch), CKD-calcium carbonate, or CKD-sevelamer groups. We measured creatinine, phosphorus, calcium, alkaline phosphatase, phosphorus excretion fraction, parathyroid hormone, and fibroblast growth factor 23. Vascular calcification was assessed using the aortic calcium content, and a semi-quantitative analysis was performed using Von Kossa and hematoxylin-eosin staining. At week seven, rats in the chronic kidney disease group had higher creatinine, phosphorus, phosphorus excretion fraction, calcium, alkaline phosphatase, fibroblast growth factor 23, and aortic calcium content than those in the Control group. Treatments with cross-linked chitosan iron (III) and calcium carbonate prevented phosphorus increase (20%-30% reduction). The aortic calcium content was l...Continue Reading

References

Jan 1, 1986·Nephron·T YokozawaF Koizumi
Aug 10, 2000·The Journal of Pharmacy and Pharmacology·J BaxterT Yamaguchi
Sep 29, 2000·Circulation Research·S JonoC M Giachelli
Jul 14, 2001·International Journal of Pharmaceutics·C BürgerC A Rodrigues
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Serge L FerrariRené Rizzoli
Aug 3, 2005·Renal Failure·Geert J BehetsPatrick C D'Haese
Nov 29, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Keiichi TamagakiMasafumi Fukagawa
Nov 6, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Olivier PhanZiad A Massy
Jan 16, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ellen NevenVeerle Persy
Aug 6, 2009·Clinical and Experimental Nephrology·Sachiko MuneTakashi Shigematsu
Jan 15, 2010·Basic & Clinical Pharmacology & Toxicology·Lisiane M R SchöningerCristiani Bürger
Apr 24, 2010·American Journal of Nephrology·Navid ShobeiriRachel M Holden
Jul 29, 2010·Nature Reviews. Cardiology·Andrew P SageLinda L Demer
Feb 22, 2011·Renal Failure·Stephen J P Damment
Aug 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Melani R CustódioVanda Jorgetti
Jan 14, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Biagio Di IorioUNKNOWN INDEPENDENT Study Investigators
Oct 10, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Wei Ling LauCecilia M Giachelli
Feb 16, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Ju-Yi ChenYau-Sheng Tsai
Mar 15, 2013·Kidney International·Tineke M De SchutterEllen Neven
Apr 4, 2013·Kidney & Blood Pressure Research·Hagen StaudeDagmar-Christiane Fischer
May 24, 2013·The Journal of Pharmacology and Experimental Therapeutics·Olivier PhanMichel Burnier
Feb 7, 2014·Journal of Nephrology·Takuya SetoYasuhiko Tomino
Jan 30, 2015·Saudi Medical Journal·Akram M Askar

❮ Previous
Next ❯

Citations

Dec 4, 2021·Experimental Biology and Medicine·Wander Barros do CarmoHelady Sanders-Pinheiro

❮ Previous
Next ❯

Methods Mentioned

BETA
urine sampling

Software Mentioned

SPSS

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.