Abstract
Since the onset of cross hormone therapy (CHT) in transsexual individuals, there has been concern about possible chronic side effects. Our objective was to assess baseline differences in lipid profile in individuals with gender identity disorder in relation to prior CHT, and changes in the lipid profile and other cardiovascular (CV) risk factors after 24 months of treatment. Retrospective longitudinal study including all individuals assisted for the first time in the Gender Identity Unit of Catalonia from 2006 to 2010. Socio-demographical, anthropometric and laboratory data were collected. We evaluated 247 transsexuals, 150 male to female (MtF: 60.7%) and 97 female to male (FtM; 39.3%). At baseline, FtM transsexuals were younger and had started prior CHT less often than MtF (13.4% vs. 64.7%; p<0.001). During follow up, in MtF weight and BMI increased significantly, as well as systolic and diastolic blood pressure, though these latter remained within normal range. No significant differences in lipid profile were observed. FtM transsexuals also presented an increase in weight and BMI, without differences in blood pressure. A general worsening in lipid profile was observed in this group, with increased total cholesterol (166.0 ± 3...Continue Reading
References
Jan 1, 1995·Maturitas·H H GohS S Ratnam
Nov 28, 1997·Clinical Endocrinology·P J van KesterenL J Gooren
Aug 26, 1998·JAMA : the Journal of the American Medical Association·S HulleyE Vittinghoff
Mar 3, 2001·Human Reproduction·M W EltingJ Schoemaker
Apr 18, 2003·Clinical Endocrinology·Jolanda M H ElbersLouis J G Gooren
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·A W F T TooriansJ Rosing
Aug 4, 2004·European Journal of Internal Medicine·Manuel SosaDiego Hernández
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·David S Guzick
Sep 1, 2006·International Journal of Impotence Research·G M C RosanoM Fini
Nov 1, 2007·The Journal of Sexual Medicine·Louis J G Gooren, Erik J Giltay
Nov 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Louis J GoorenMathijs C Bunck
Jan 27, 2011·European Journal of Endocrinology·Henk AsschemanLouis J G Gooren
Mar 3, 2011·PloS One·Cecilia DhejneMikael Landén
May 21, 2011·The Journal of Sexual Medicine·Johannes OttUlrike Kaufmann
Citations
Apr 17, 2016·The Lancet. Diabetes & Endocrinology·Michael S Irwig
Aug 31, 2016·Andrologia·M KlaverM den Heijer
Mar 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael S Irwig
Mar 31, 2018·Andrology·J DefreyneG T'Sjoen
Aug 4, 2018·Reviews in Endocrine & Metabolic Disorders·Michael S Irwig
Jul 20, 2018·Clinical Endocrinology·Giulia GavaMaria C Meriggiola
Oct 12, 2018·Endocrine Reviews·Guy T'SjoenVin Tangpricha
Apr 3, 2020·Praxis·Lucia Wehrle
Oct 18, 2019·JRSM Cardiovascular Disease·Leighton J Seal
Oct 20, 2018·LGBT Health·Jeremy D KiddWalter O Bockting
Nov 26, 2019·Clinical Endocrinology·Barbara I GulanskiNina S Stachenfeld
Mar 30, 2018·Archives of Sexual Behavior·Şenol TuranAlaattin Duran
Jul 31, 2020·Biology of Sex Differences·Tori Stone, Nina S Stachenfeld
Aug 19, 2020·Journal of Hypertension·Paul J ConnellyChristian Delles
Apr 20, 2021·Hypertension·Katherine BanksMichael S Irwig
Aug 18, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M KyinnM S Irwig
Nov 14, 2020·Clinical Nutrition ESPEN·M RozgaE K Gradwell