Effect of culling and vaccination on bovine tuberculosis infection in a European badger (Meles meles) population by spatial simulation modelling

Preventive Veterinary Medicine
Marwa AbdouAndrew W Byrne

Abstract

The control of bovine tuberculosis (bTB) in cattle herds in the Republic of Ireland (ROI) is partially hindered by spill-back infection from wild badgers (Meles meles). The aim of this study was to determine the relative effects of interventions (combinations of culling and/or vaccination) on bTB dynamics in an Irish badger population. A spatial agent-based stochastic simulation model was developed to evaluate the effect of various control strategies for bovine tuberculosis in badgers: single control strategies (culling, selective culling, vaccination, and vaccine baits), and combined strategies (Test vaccinate/cull (TVC)), split area approaches using culling and vaccination, or selective culling and vaccination, and mixed scenarios where culling was conducted for five years and followed by vaccination or by a TVC strategy. The effect of each control strategy was evaluated over a 20-year period. Badger control was simulated in 25%, 50%, and 75% area (limited area strategy) or in the entire area (100%, wide area strategy). For endemic bTB, a culling strategy was successful in eradicating bTB from the population only if applied as an area-wide strategy. However, this was achieved only by risking the extinction of the badger popul...Continue Reading

References

Sep 12, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R M Anderson, W Trewhella
Aug 1, 1995·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L M O'Reilly, C J Daborn
Sep 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P C White, S Harris
Sep 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P C White, S Harris
Dec 22, 2000·Research in Veterinary Science·J Gallagher, R S Clifton-Hadley
Jun 1, 2002·Journal of Wildlife Diseases·A K SoutheyE Gormley
Nov 25, 2003·Nature·Christl A DonnellyW Ivan Morrison
Mar 8, 2005·Preventive Veterinary Medicine·J M GriffinS J More
Jan 3, 2006·Veterinary Microbiology·Charles ThoenIsabel de Kantor
Apr 1, 2011·Veterinary Microbiology·Inma AznarMart C M De Jong
Apr 13, 2011·Veterinary Microbiology·Michael Sheridan
Apr 14, 2011·The Veterinary Journal·Eamonn Gormley, Leigh A L Corner
Feb 22, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Philip A RobinsonDarrell A Abernethy
May 1, 2012·The Veterinary Journal·Leigh A L CornerE Gormley
Jan 15, 2014·The Journal of Animal Ecology·Andrew W ByrneJohn Davenport
May 6, 2014·The Veterinary Journal·Bryce M Buddle, Geoffrey W de Lisle
May 20, 2014·The Veterinary Record·G McGrathS J More
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jon BielbyRosie Woodroffe
May 15, 2015·Proceedings. Biological Sciences·Ellen Brooks-Pollock, James L N Wood

❮ Previous
Next ❯

Citations

Sep 25, 2016·Research in Veterinary Science·D RiscoP Fernández-Llario
Mar 7, 2019·Journal of the Royal Society, Interface·Jamie C PrenticeGlenn Marion
Sep 22, 2020·PLoS Neglected Tropical Diseases·Scott L NuismerElisabeth Fichet-Calvet
Nov 22, 2018·Frontiers in Veterinary Science·Graham C Smith, Richard J Delahay
Nov 13, 2018·Frontiers in Veterinary Science·Bryce M BuddleLin-Mari de Klerk-Lorist

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.