Effect of Curcuma longa and Ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury

BMC Complementary and Alternative Medicine
Ipseeta MohantySuresh Kumar Gupta

Abstract

In the present investigation, the effect of Curcuma longa (Cl) and Ocimum sanctum (Os) on myocardial apoptosis and cardiac function was studied in an ischemia and reperfusion (I-R) model of myocardial injury. Wistar albino rats were divided into four groups and orally fed saline once daily (sham, control IR) or Cl (100 mg/kg; Cl-IR) or Os (75 mg/kg; Os-IR) respectively for 1 month. On the 31st day, in the rats of the control IR, Cl-IR and Os-IR groups LAD occlusion was undertaken for 45 min, and reperfusion was allowed for 1 h. The hemodynamic parameters{mean arterial pressure (MAP), heart rate (HR), left ventricular end-diastolic pressure (LVEDP), left ventricular peak positive (+) LVdP/dt (rate of pressure development) and negative (-) LVdP/dt (rate of pressure decline)} were monitored at pre-set points throughout the experimental duration and subsequently, the animals were sacrificed for immunohistopathological (Bax, Bcl-2 protein expression & TUNEL positivity) and histopathological studies. Chronic treatment with Cl significantly reduced TUNEL positivity (p < 0.05), Bax protein (p < 0.001) and upregulated Bcl-2 (p < 0.001) expression in comparison to control IR group. In addition, Cl demonstrated mitigating effects on sever...Continue Reading

References

Feb 1, 1992·Archives of Biochemistry and Biophysics·L SrinivasM Shylaja
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jan 1, 1994·Immunology Today·T M Buttke, P A Sandstrom
Dec 22, 1993·Molecular and Cellular Biochemistry·P K SingalT P Thomas
Jun 21, 1996·Molecular and Cellular Biochemistry·C Nirmala, R Puvanakrishnan
Nov 1, 1996·Circulation Research·H Fliss, D Gattinger
Jan 21, 1997·Circulation·A SarasteL M Voipio-Pulkki
Aug 1, 1997·Circulation Research·W R MacLellan, M D Schneider
May 20, 1998·Free Radical Biology & Medicine·N MaulikD K Das
Jun 20, 1998·Circulation Research·A Haunstetter, S Izumo
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·J NarulaS Kharbanda
Apr 27, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M A KelmD L DeWitt
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E PalojokiI Tikkanen
Jul 26, 2003·Nutrition and Cancer·Chandra KiranaGraham P Jones

❮ Previous
Next ❯

Citations

Oct 31, 2013·Chinese Journal of Integrative Medicine·Youngmin BuSang-Kwan Moon
Aug 30, 2013·Canadian Journal of Physiology and Pharmacology·Peihan XuZheng Zhang
Nov 27, 2015·Canadian Journal of Physiology and Pharmacology·Hong DanNianbai Fang
Sep 3, 2008·Journal of Ethnopharmacology·A MuthuramanDhandeep Singh
Feb 12, 2009·Clinical and Experimental Pharmacology & Physiology·Zhao-Yang Hu, Jin Liu
Oct 31, 2019·Journal of Cardiovascular Translational Research·Jing ShaoXin Ma
Jan 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Azar Hosseini, Hossein Hosseinzadeh

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.