Effect of curcumin on the apoptosis of rodent and human nonproliferating and proliferating lymphoid cells

Nutrition and Cancer
Anna Bielak-ZmijewskaEwa Sikora

Abstract

Curcumin, a major active component of turmeric, has been recognized as an anticarcinogenic agent because of its propensity to induce apoptosis in vivo and in vitro. Previously, we showed that curcumin protects cells against oligonucleosomal DNA fragmentation and induces a novel apoptosis-like pathway in Jurkat cells (Piwocka et al. Exp Cell Res 249, 299-307, 1999). Here, we have studied the ability of curcumin to induce cell death in other human and rodent transformed as well as normal cells. Normal cells were quiescent or stimulated to proliferate. We showed that 50 microM pigment is able to induce cell death in all studied cells, but cell death symptoms varied for different cells. All the cells died as assessed by the TdT-mediated UTP nick end labeling method or trypan blue exclusion test. No one type of cells showed oligonucleosomal DNA fragmentation (DNA "ladder") due to curcumin action, although in HL-60 cells, we were able to observe sub-G1 formation and caspase-3 activation. Together, these data showed that curcumin induces cell death in all tested cells that can be classified as apoptosis-like, and only in HL-60 cells can it be recognized as classical apoptosis.

References

Nov 10, 1995·The Journal of Biological Chemistry·H SawaiH Umehara
Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·G J KelloffC C Sigman
Apr 18, 1998·The Journal of Biological Chemistry·J M ZapataJ C Reed
Aug 28, 1998·British Journal of Pharmacology·H W Chen, H C Huang
Apr 14, 1999·Cell Death and Differentiation·K S FamulskiE Sikora
Nov 24, 1999·Cell Biology International·E RadziszewskaE Sikora

❮ Previous
Next ❯

Citations

Jul 11, 2009·The AAPS Journal·Jayaraj RavindranBharat B Aggarwal
Mar 11, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Carmen Martín-CorderoMaria Jesús Ayuso
Dec 21, 2006·Clinical and Experimental Immunology·S SharmaJ N Agrewala
Nov 14, 2015·Clinical Nutrition Research·Anjali GanjreVivek Pawar
Nov 16, 2016·Bioorganic & Medicinal Chemistry Letters·Atiruj TheppawongMatthias D'hooghe
Aug 1, 2006·FEBS Letters·Grazyna MosieniakEwa Sikora
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Adriana MagalskaEwa Sikora
Apr 16, 2002·Journal of Internal Medicine·R M TamimiD Trichopoulos
Jan 11, 2007·Journal of Clinical Immunology·Ganesh Chandra Jagetia, Bharat B Aggarwal
Nov 24, 2006·Archives of Pharmacal Research·Songyot AnuchapreedaPornngarm Limtrakul
Dec 18, 2002·Annals of the New York Academy of Sciences·Katarzyna PiwockaEwa Sikora
Aug 25, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xinjian Li, Xiaocheng Liu
May 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M XinD Zhou
Apr 26, 2019·Human & Experimental Toxicology·L A Méndez-GarcíaE J Córdova
Mar 16, 2019·International Journal of Molecular Sciences·Anna Bielak-ZmijewskaEwa Sikora
Jul 27, 2021·Current Therapeutic Research, Clinical and Experimental·Lei SongJunxi Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Transplantation Proceedings
M B RegazziM Rinaldi
Asian Pacific Journal of Cancer Prevention : APJCP
Patompong Khaw-on, Ratana Banjerdpongchai
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Chunyan SunFang Liu
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yan ChenWenjuan Chen
© 2021 Meta ULC. All rights reserved