PMID: 18727865Aug 30, 2008Paper

Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1 mRNA in pulmonary fibrosis rats

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Bi ChenWei Gao

Abstract

To study the effects of curcumin on the expressions of collagen type I protein and transforming growth factor-beta1 mRNA in lung tissues of rats with pulmonary fibrosis. 96 male SD rats were randomly divided into four groups with 24 rats in each group: the normal control group, the model group, the prednisone treated group, and the curcumin treated group. Pulmonary fibrosis was induced by intra-bronchial injection of bleomycin A5. From the 15(th) day after bleomycin administration, rats in the prednisone treated group and the curcumin treated group were given prednisone (5 mg/kg) or curcumin (300 mg/kg) respectively once daily by intragastric administration. In the same way, rats in the normal control group and the model group were given 1% Sodium Carboxymethyl Cellulose (10 ml/kg) once daily. The histological changes of lung tissue were evaluated by Haematoxylin-eosin (HE) and Masson's trichrome. The rats were randomly sacrificed on the 21(st), 28(th), 42(nd) and 56(th) day after bleomycin administration. The type I collagen expression was analyzed by immunohistochemistry. The transforming growth factor-beta(1) (TGF-beta(1)) mRNA expression of lung was detected by the semi-quantitative reverse transcription polymerase chain re...Continue Reading

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