Abstract
Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We observed the cellular morphology and determined the migration, invasion, proliferation, and apoptosis of A375 cells in vitro. Our results showed that curcumin induced a significant change in the morphology of A375 cells. Compared to the control group, the groups treated with curcumin showed significantly wider scratches, and the number of A375 cells significantly decreased in the 12.5, 25, and 50 mM curcumin groups (P < 0.05 or < 0.01). The rates of proliferation inhibition in the 5 curcumin groups were 19.38 ± 3.57%, 35.56 ± 4.37%, 63.98 ± 5.95%, 86.38 ± 3.91%, and 95.56 ± 3.15%. The half-maximal inhibitory concentration of curcumin at 48 h was 10.05 mM. The rates of apoptosis in 6.25 and 12.5 mM curcumin groups were significantly higher (P < 0.05), phosphorylation levels of JAK-2 and STAT-3 in 10 and 20 mM curcumin groups were significantly lower (P < 0.05)...Continue Reading
Citations
Nov 12, 2016·Nutrients·Aline Renata PavanJean Leandro Dos Santos
Jan 31, 2017·Cancer Letters·Ross L PearlmanFarrukh Afaq
Aug 30, 2017·Food & Function·Xiao-Ping WangNa Chang
Oct 27, 2018·International Journal of Cancer. Journal International Du Cancer·AmirReza HesariHamed Mirzaei
Aug 11, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Janet Y Li, Jeremy T Kampp
Dec 12, 2018·Journal of Liposome Research·Malleswara Rao PeramPrakash Diwan
Jul 13, 2019·AAPS PharmSciTech·Gayathri Heenatigala PalliyageHarsh Chauhan
Jun 22, 2019·Molecular and Cellular Biochemistry·Weijie HanQiuhong Wang
Apr 8, 2020·Phytotherapy Research : PTR·Ting XuYumeng Wei
May 12, 2016·American Journal of Clinical Dermatology·Adilson CostaJack L Arbiser
Jul 21, 2017·Journal of Cellular Biochemistry·Xinqian DongJunlong Xu
Jan 5, 2018·Nutrition and Cancer·Seyed Mohammad NabaviZohreh Hajheydari
Nov 30, 2018·Journal of Cellular Biochemistry·Jia QiAn-Quan Shang
May 10, 2019·Hepatology International·Hang LiXianfeng Gan
Oct 4, 2019·PeerJ·Hong LiYuhui Tan
Mar 12, 2020·Phytotherapy Research : PTR·Milad AshrafizadehSaeed Samarghandian
Jun 10, 2016·International Journal of Cancer. Journal International Du Cancer·Hamed MirzaeiAmirhossein Sahebkar
Mar 13, 2020·Drug Design, Development and Therapy·Dapeng ZhangZhenguo Cheng
Jun 25, 2019·Seminars in Cancer Biology·Fabrizio FontanaPatrizia Limonta
Sep 21, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wang LiaoYan Ding
Feb 18, 2021·Environmental Science and Pollution Research International·Madhuri GroverDhruv Setia
Aug 14, 2020·Life Sciences·Sahar El-Sayed ElswefyHebatallah Husseini Atteia
Aug 25, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tejinder Pal KhaketSun Chul Kang
Nov 5, 2020·Recent Patents on Anti-cancer Drug Discovery·Saleh A AlmatroodiArshad Husain Rahmani