Effect of Cuscuta reflexa Roxb on androgen-induced alopecia

Journal of Cosmetic Dermatology
Shweta PanditV K Dixit

Abstract

Alopecia is a psychologically distressing condition. Androgenetic alopecia, which affects millions of men and women, is an androgen-driven disorder. Here, Cuscuta reflexa Roxb is evaluated for hair growth activity in androgen-induced alopecia. Petroleum ether extract of C. reflexa was studied for its hair growth-promoting activity. Alopecia was induced in albino mice by testosterone administration for 20 days. Its inhibition by simultaneous administration of extract was evaluated using follicular density, anagen/telogen ratio, and microscopic observation of skin sections. To investigate the mechanism of observed activity, in vitro experiments were performed to study the effect of extract and its major component on activity of 5alpha-reductase enzyme. Petroleum ether extract of C. reflexa exhibited promising hair growth-promoting activity as reflected from follicular density, anagen/telogen ratio, and skin sections. Inhibition of 5alpha-reductase activity by extract and isolate suggest that the extract reversed androgen-induced alopecia by inhibiting conversion of testosterone to dihydrotestosterone. The petroleum ether extract of C. reflexa and its isolate is useful in treatment of androgen-induced alopecia by inhibiting the en...Continue Reading

References

Mar 1, 1997·Journal of Pharmacological and Toxicological Methods·M P Purdon, L D Lehman-McKeeman
Aug 10, 2000·Fitoterapia·A CristoniE Bombardelli
Dec 26, 2001·Urology·W D Steers
Feb 8, 2003·Molecular and Cellular Endocrinology·Keith D Kaufman
Mar 15, 2005·Steroids·Víctor Pérez-OrnelasElia Naranjo-Rodríguez
May 26, 2007·Journal of Cosmetic Dermatology·Ram Kumar RoyV K Dixit

Citations

Dec 14, 2011·Archives of Dermatological Research·Kirti UpadhyayVinod Kumar Dixit
Sep 19, 2009·Natural Product Research·Renuka DhanotiaVinod K Dixit
Mar 14, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Satish PatelVinod Kumar Dixit
Jan 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Satish PatelVinod Kumar Dixit
May 23, 2014·American Journal of Clinical Dermatology·Supenya Varothai, Wilma F Bergfeld
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruchy JainWanchai De-Eknamkul
Nov 27, 2015·Journal of Cosmetic Dermatology·Mariangela RondanelliDavide Guido
Apr 20, 2011·Phytotherapy Research : PTR·Alok Nahata, Vinod Kumar Dixit
Sep 3, 2013·Journal of Cosmetic Dermatology·Nattaya Lourith, Mayuree Kanlayavattanakul
May 31, 2014·Expert Opinion on Therapeutic Targets·Ruchy Jain, Wanchai De-Eknamkul
May 28, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Young Hye ChoHyeong Soo Cha
Oct 1, 2010·Current Therapeutic Research, Clinical and Experimental·Chetan NandechaVinod Kumar Dixit
Oct 15, 2013·Natural Product Research·Prajwal PaudelWilliam N Setzer
Jul 12, 2017·Archives of Dermatological Research·Anna Herman, Andrzej P Herman
Oct 22, 2020·BioMed Research International·Waseem HassanEl-Shaimaa A Arafa

Related Concepts

Androgen Effect
Downy Hair
Phytotherapy
Petroleum
Plant Extracts
Sterotate
Testosterone 5-alpha-Reductase
Hair Follicle Structure
Cuscuta
5-alpha Reductase Inhibitors

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.