PMID: 25735334Mar 5, 2015Paper

Effect of CXCR4 and CD133 co-expression on the prognosis of patients with stage II~III colon cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Xiao-Feng LiAi-Yong Liu

Abstract

To explore the relationship between CXCR4, CD133 co-expression and clinicopathological features as well as prognosis of patients with phase II~III colon cancer. Forty-nine paraffin-embedded samples of tumor tissue and epithelial tissue adjacent to cancer were collected from patients with colon cancer undergoing radical surgery in Baotou Cancer Hospital from January, 2010 to June, 2011. CXCR4 and CD133 expression was detected using immunohistochemistry and its relationship with clinicopathological features and the 3-year survival rate was analyzed. In the tumor tissue and colonic epithelial tissue adjacent to cancer, the positive expression rates of CXCR4 were respectively 61.2% (30/49) and 8.16% (4/49), while those of CD133 being 36.7% (18/49) and 6.12% (3/49). CXCR4 and CD133 expression in tumor tissue was not related to patient age, gender, primary focal sites, tumor size, TNM staging, histological type, tumor infiltration depth and presence or absence of lymphatic metastasis, but CXCR4 and CD133 co-expression was associated with TNM staging and lymphatic metastasis. The 3-year survival rate of patients with CXCR4 and CD133 co-expression was 27.3% (3/11), and that of the remainderwas 76.3% (29/38), the difference being signif...Continue Reading

References

May 18, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Yan WuJin Liu
Dec 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jingxun WuHanxiang An
Jan 1, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Liu YangXin Guan
Jan 10, 2014·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Cheng-Zhi XuRun-Jie Shi
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Quan YaoZheng-Tang Chen
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Ping GongDong-Feng Wang
Mar 22, 2014·Molecular and Clinical Oncology·Yaoxi TanJianqing Wu
Jun 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weimin WangJianwei Zhou
Aug 2, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Xue-Yan WuZhi-Ying Qian

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Citations

Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yao-Ping LiYongping Cui
Dec 22, 2016·International Journal of Oncology·Zhenbo TuQiuping Zhang

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