PMID: 6323323Jan 1, 1984Paper

Effect of cyclic AMP-elevating agents on human spontaneous IgE synthesis in vitro

International Archives of Allergy and Applied Immunology
O Strannegård, I L Strannegård

Abstract

The cyclic AMP (cAMP)-elevating substances dibutyryl-cAMP (dbcAMP), isoproterenol and theophylline were found to suppress the spontaneous in vitro IgE synthesis of peripheral blood mononuclear cells (MNC) from patients with atopic dermatitis, when added at high concentrations (10(-3) -10(-4) M) to the IgE-producing cell cultures. In contrast, low concentrations of the substances (10(-8) -10(-12) M) significantly enhanced IgE production. This enhancement was probably due to effects of cAMP on T cells since pretreatment of allogeneic MNC or T cells with dbcAMP abrogated their suppressive effect or resulted in enhancement of IgE synthesis in coculture experiments. Likewise, pretreated T cells from atopics stimulated the IgE production of autologous B cells more than did untreated T cells. These findings may possibly have bearing on the pathogenesis of the atopic diseases, which are associated with abnormalities of the cyclic nucleotide metabolism.

Citations

May 5, 2000·Biochemical Pharmacology·D M Essayan
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·T J Torphy
Feb 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B C MelnikT Tschung
Jan 29, 2011·Pharmacological Reports : PR·Marianna Szczypka, Bożena Obmińska-Mrukowicz
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S S SalviS T Holgate

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.