Effect of cyclic guanosine-monophosphate on porcine retinal vasomotion

Acta Ophthalmologica Scandinavica
Anders HessellundToke Bek

Abstract

Vasomotion refers to periodic oscillations in vascular tone that ensure the intermittent supply of blood to adjacent microvascular units. Previous evidence from vessels outside the eye suggests that cyclic guanosine-monophosphate (cGMP) is involved in the regulation of vasomotion, but it is unknown whether this compound has an effect on vasomotion in retinal vessels. Retinal arterioles from porcine eyes were studied in a wire myograph. After initiation of vasomotion, the vessels were stimulated with increasing concentrations of the cGMP agonist 8-Br-cGMP (n = 6), the phosphodiesterase inhibitor zaprinast (n = 6) and the cGMP synthesis inhibitor L-NAME (n = 6). High concentrations of L-NAME blocked vasomotion, and control experiments (n = 20) using 8-Br-cGMP, S-nitroso-N-acetylpenicillamine (SNAP), adenosine and pinacidil were carried out to elucidate whether this effect was related to changes in the general tone of the vessel. Additionally, the relationship between oscillations in vascular tone and intracellular calcium concentration was studied. Induction of cGMP agonistic activity with either 8-Br-cGMP or zaprinast lowered the vasomotion frequency significantly, whereas L-NAME-induced inhibition of cGMP increased this frequen...Continue Reading

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Citations

Feb 13, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Toke BekPeter Jeppesen
Jan 30, 2013·Bulletin of Mathematical Biology·James HadfieldTim David
Jul 18, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Oct 5, 2010·Acta Physiologica·R K Pradhan, V S Chakravarthy
Apr 27, 2011·Acta Physiologica·C AalkjærV Matchkov
Jul 31, 2013·Progress in Retinal and Eye Research·Toke Bek
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Feb 26, 2019·Acta Ophthalmologica·Toke Bek

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Acta Ophthalmologica Scandinavica
Anders HessellundToke Bek
Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Toke Bek
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