Effect of cyclooxygenase inhibitors on the micturition reflex in rats: correlation with inhibition of cyclooxygenase isozymes

BJU International
Patrizia AngelicoRodolfo Testa

Abstract

To investigate the role of cyclooxygenase (COX) isozymes (COX-1 and -2) in the regulation of bladder volume capacity (BVC) in several rat urodynamic models, using a selection of nonsteroidal anti-inflammatory drugs (NSAIDs), some selective for COX-2, correlating the potency of the tested compounds in the urodynamic models and their in vitro potency as inhibitors of COX isozymes, to verify the relative importance of the different isozymes. The effects of an i.v. administration of several nonselective and selective COX-2 inhibitors (indomethacin, meloxicam, naproxen, aspirin, paracetamol, flurbiprofen, nimesulide, NS-398, celecoxib, rofecoxib and L 745337) on bladder filling and voiding were evaluated in conscious and anaesthetized rats by cystometry. The cystometry was done in conscious rats 1 day after catheter implantation, by filling the bladder with dilute acetic acid (0.2%) or saline, and again with saline 5 days after catheterization. Effects on isovolumic bladder contractions in anaesthetized rats were also evaluated. All the NSAIDs tested dose-dependently increased BVC; their potency at increasing BVC during infusion of the bladder with acetic acid was similar to that evaluated with saline on cystometry 1 day after cathe...Continue Reading

References

Apr 1, 1990·Japanese Journal of Pharmacology·K MorikawaY Gomi
Jan 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C A Maggi
Apr 10, 1990·European Journal of Pharmacology·R A FerrariD R Haubrich
Aug 1, 1989·Japanese Journal of Pharmacology·K MorikawaY Gomi
Aug 2, 1988·European Journal of Pharmacology·C A MaggiA Meli
Jan 12, 1988·European Journal of Pharmacology·C A MaggiA Meli
May 1, 1995·The Journal of Comparative Neurology·C D BrederR P Kraig
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Jan 5, 2002·Journal of Pharmacological and Toxicological Methods·C VelascoR Testa
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons

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Citations

Jan 16, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·Emilio SaccoPierfrancesco Bassi
May 1, 2008·Current Prostate Reports·Jennifer L St Sauver, Steven J Jacobsen
Sep 4, 2008·Expert Opinion on Emerging Drugs·Marcus J Drake
Oct 27, 2010·Neurourology and Urodynamics·Naoki Aizawa, Jean-Jacques Wyndaele
Nov 2, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Kang Jun Cho, Joon Chul Kim
Jun 11, 2011·Neurourology and Urodynamics·Karl-Erik AnderssonClaudius Füllhase
Oct 28, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Konstantinos KamperisJens C Djurhuus
Jun 29, 2007·Neurourology and Urodynamics·Xin SuNicholas J Laping
Sep 13, 2007·Neurourology and Urodynamics·Phillip P SmithGeorge T Somogyi
Mar 14, 2012·Nature Reviews. Urology·Mohammad S Rahnama'iGommert A van Koeveringe
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary Beth KlingerMargaret A Vizzard
May 30, 2008·American Journal of Physiology. Renal Physiology·Gerald P McCaffertyKevin S Thorneloe
Jun 20, 2008·American Journal of Physiology. Renal Physiology·Xin SuNicholas J Laping
Jul 18, 2008·American Journal of Physiology. Renal Physiology·Xin SuNicholas J Laping
Dec 15, 2020·Biochemical Pharmacology·Ruida HouJianxiong Jiang

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